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Parn poly(A)-specific ribonuclease (deadenylation nuclease) [ Mus musculus (house mouse) ]

Gene ID: 74108, updated on 19-Jul-2014
Official Symbol
Parnprovided by MGI
Official Full Name
poly(A)-specific ribonuclease (deadenylation nuclease)provided by MGI
Primary source
MGI:1921358
See related
Ensembl:ENSMUSG00000022685
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DAN; 1200003I18Rik
See Parn in Epigenomics, MapViewer
Location:
16; 16 B1
Exon count :
24
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 16 NC_000082.6 (13537960..13668170, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102635495 Neighboring gene microRNA mir-6365 Neighboring gene RIKEN cDNA 2310015D24 gene Neighboring gene uncharacterized LOC102636296 Neighboring gene non-histone chromosomal protein HMG-14-like Neighboring gene uncharacterized LOC102636123 Neighboring gene RIKEN cDNA 3110001I22 gene Neighboring gene bifunctional apoptosis regulator Neighboring gene phospholipase A2, group X Neighboring gene phospholipase A2, group X, opposite strand

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
poly(A)-specific ribonuclease activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
 
nuclear-transcribed mRNA poly(A) tail shortening IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
poly(A)-specific ribonuclease PARN
Names
poly(A)-specific ribonuclease PARN
polyadenylate-specific ribonuclease
NP_083037.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028761.3NP_083037.1  poly(A)-specific ribonuclease PARN

    See proteins identical to NP_083037.1

    Status: PROVISIONAL

    Source sequence(s)
    AC154564, AC154607
    Consensus CDS
    CCDS37259.1
    UniProtKB/Swiss-Prot
    Q8VDG3
    Related
    ENSMUSP00000055969, ENSMUST00000058884
    Conserved Domains (3) summary
    cd02637
    Location:174238
    Blast Score: 258
    R3H_PARN; R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the ...
    pfam04857
    Location:1385
    Blast Score: 470
    CAF1; CAF1 family ribonuclease
    cd12428
    Location:437502
    Blast Score: 273
    RRM_PARN; RNA recognition motif in poly(A)-specific ribonuclease PARN and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000082.6 

    Range
    13537960..13668170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522652.1XP_006522715.1  

    See proteins identical to XP_006522715.1

    Conserved Domains (3) summary
    cd02637
    Location:113177
    Blast Score: 259
    R3H_PARN; R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the ...
    pfam04857
    Location:1324
    Blast Score: 310
    CAF1; CAF1 family ribonuclease
    cd12428
    Location:376441
    Blast Score: 274
    RRM_PARN; RNA recognition motif in poly(A)-specific ribonuclease PARN and similar proteins
  2. XM_006522651.1XP_006522714.1  

    Conserved Domains (3) summary
    cd02637
    Location:194243
    Blast Score: 174
    R3H_PARN; R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the ...
    pfam04857
    Location:35390
    Blast Score: 465
    CAF1; CAF1 family ribonuclease
    cd12428
    Location:442507
    Blast Score: 272
    RRM_PARN; RNA recognition motif in poly(A)-specific ribonuclease PARN and similar proteins
  3. XM_006522650.1XP_006522713.1  

    Conserved Domains (3) summary
    cd02637
    Location:201265
    Blast Score: 261
    R3H_PARN; R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the ...
    pfam04857
    Location:35393
    Blast Score: 460
    CAF1; CAF1 family ribonuclease
    cd12428
    Location:445510
    Blast Score: 273
    RRM_PARN; RNA recognition motif in poly(A)-specific ribonuclease PARN and similar proteins
  4. XM_006522649.1XP_006522712.1  

    Conserved Domains (3) summary
    cd02637
    Location:201265
    Blast Score: 262
    R3H_PARN; R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the ...
    pfam04857
    Location:35412
    Blast Score: 444
    CAF1; CAF1 family ribonuclease
    cd12428
    Location:464529
    Blast Score: 273
    RRM_PARN; RNA recognition motif in poly(A)-specific ribonuclease PARN and similar proteins

Alternate Mm_Celera

Genomic

  1. AC_000038.1 

    Range
    14141614..14273156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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