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Htt huntingtin [ Mus musculus (house mouse) ]

Gene ID: 15194, updated on 18-Aug-2014
Official Symbol
Httprovided by MGI
Official Full Name
huntingtinprovided by MGI
Primary source
MGI:96067
See related
Ensembl:ENSMUSG00000029104; Vega:OTTMUSG00000023182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hd; Hdh; IT15; AI256365; C430023I11Rik
Location:
5 B2; 5 17.92 cM
Exon count:
67
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 5 NC_000071.6 (34761737..34912521)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102633804 Neighboring gene NOP14 nucleolar protein Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene Myb/SANT-like DNA-binding domain containing 1 Neighboring gene regulator of G-protein signaling 12 Neighboring gene microRNA 3097 Neighboring gene hepatocyte growth factor activator

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
diazepam binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
dynactin binding ISO
Inferred from Sequence Orthology
more info
 
dynein intermediate chain binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
p53 binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi organization ISO
Inferred from Sequence Orthology
more info
 
L-glutamate import IMP
Inferred from Mutant Phenotype
more info
PubMed 
anatomical structure morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon cargo transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
citrulline metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
grooming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lactate biosynthetic process from pyruvate IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA transport ISO
Inferred from Sequence Orthology
more info
 
mitochondrial transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
 
neural plate formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
olfactory lobe development IMP
Inferred from Mutant Phenotype
more info
PubMed 
paraxial mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptide hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
quinolinate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrial membrane permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein phosphatase type 2A activity ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to calcium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER ISO
Inferred from Sequence Orthology
more info
 
social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
striatum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
urea cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle transport along microtubule IDA
Inferred from Direct Assay
more info
PubMed 
vesicle transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
autophagic vacuole ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic membrane-bounded vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
late endosome ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with neuronal ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
huntingtin
Names
huntingtin
HD protein homolog
Huntington disease gene homolog
huntington disease protein homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010414.3NP_034544.1  huntingtin

    See proteins identical to NP_034544.1

    Status: VALIDATED

    Source sequence(s)
    AC133204, AC151669, BQ175932
    Consensus CDS
    CCDS19220.1
    UniProtKB/TrEMBL
    G3X9H5
    Related
    ENSMUSP00000078945, OTTMUSP00000026909, ENSMUST00000080036, OTTMUST00000056080
    Conserved Domains (1) summary
    pfam12372
    Location:14921534
    Blast Score: 148
    DUF3652; Huntingtin protein region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000071.6 

    Range
    34761737..34912521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503744.1XP_006503807.1  

    Conserved Domains (1) summary
    pfam12372
    Location:13541396
    Blast Score: 148
    DUF3652; Huntingtin protein region

RNA

  1. XR_376798.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000027.1 

    Range
    32235862..32386417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)