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    Irf5 interferon regulatory factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 27056, updated on 30-Jul-2015
    Official Symbol
    Irf5provided by MGI
    Official Full Name
    interferon regulatory factor 5provided by MGI
    Primary source
    MGI:MGI:1350924
    See related
    Ensembl:ENSMUSG00000029771; Vega:OTTMUSG00000035855
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mirf5; AW491843
    Orthologs
    See Irf5 in Epigenomics, MapViewer
    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (29526130..29541851)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (29476733..29487319)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene 9047 Neighboring gene kielin/chordin-like protein Neighboring gene predicted gene, 26627 Neighboring gene transportin 3 Neighboring gene predicted gene, 30896 Neighboring gene predicted gene, 38780

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptidoglycan ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    interferon regulatory factor 5
    Names
    interferon regulatory factor 5 bone marrow

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252382.1NP_001239311.1  interferon regulatory factor 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC079276, AF028725, AW491843, BY749804
      UniProtKB/Swiss-Prot
      P56477
      Conserved Domains (2) summary
      cd00103
      Location:23131
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:255439
      IRF-3; Interferon-regulatory factor 3
    2. NM_001311083.1NP_001298012.1  interferon regulatory factor 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the UTRs and 5' and 3' coding regions and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AK171356, BY749561
      Consensus CDS
      CCDS80504.1
    3. NM_012057.4NP_036187.1  interferon regulatory factor 5 isoform 2

      See identical proteins and their annotated locations for NP_036187.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different 5' end, which results in the use of an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and different N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AF028725, AW491843, BY749561
      Consensus CDS
      CCDS19962.1
      UniProtKB/Swiss-Prot
      P56477
      UniProtKB/TrEMBL
      Q3U169
      Related
      ENSMUSP00000004392, OTTMUSP00000050648, ENSMUST00000004392, OTTMUST00000091864
      Conserved Domains (2) summary
      cd00103
      Location:14122
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:246430
      IRF-3; Interferon-regulatory factor 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

      Range
      29526130..29541851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505095.1XP_006505158.1  

      Conserved Domains (2) summary
      cd00103
      Location:41149
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:273457
      IRF-3; Interferon-regulatory factor 3
    2. XM_006505098.1XP_006505161.1  

      See identical proteins and their annotated locations for XP_006505161.1

      Conserved Domains (1) summary
      pfam10401
      Location:178362
      IRF-3; Interferon-regulatory factor 3
    3. XM_011241064.1XP_011239366.1  

      Related
      ENSMUSP00000126273, OTTMUSP00000072675, ENSMUST00000167252, OTTMUST00000138172
      Conserved Domains (2) summary
      cd00103
      Location:14122
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:246430
      IRF-3; Interferon-regulatory factor 3
    4. XM_006505097.1XP_006505160.1  

      See identical proteins and their annotated locations for XP_006505160.1

      UniProtKB/Swiss-Prot
      P56477
      UniProtKB/TrEMBL
      Q3U169
      Related
      ENSMUSP00000127021, OTTMUSP00000050675, ENSMUST00000163511, OTTMUST00000091896
      Conserved Domains (2) summary
      cd00103
      Location:14122
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:246430
      IRF-3; Interferon-regulatory factor 3
    5. XM_006505100.2XP_006505163.1  

      See identical proteins and their annotated locations for XP_006505163.1

      Conserved Domains (1) summary
      pfam10401
      Location:178362
      IRF-3; Interferon-regulatory factor 3
    6. XM_006505099.2XP_006505162.1  

      See identical proteins and their annotated locations for XP_006505162.1

      Conserved Domains (1) summary
      pfam10401
      Location:178362
      IRF-3; Interferon-regulatory factor 3

    Alternate Mm_Celera

    Genomic

    1. AC_000028.1 Alternate Mm_Celera

      Range
      29535471..29546164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)