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NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) [ Homo sapiens (human) ]

Gene ID: 8996, updated on 19-Jul-2014
Official Symbol
NOL3provided by HGNC
Official Full Name
nucleolar protein 3 (apoptosis repressor with CARD domain)provided by HGNC
Primary source
HGNC:7869
See related
Ensembl:ENSG00000140939; HPRD:05572; MIM:605235; Vega:OTTHUMG00000173316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARC; FCM; MYP; NOP; NOP30
Summary
This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
See NOL3 in Epigenomics, MapViewer
Location:
16q22.1
Exon count :
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (67170497..67175737)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67204400..67209640)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene TNFRSF1A-associated via death domain Neighboring gene F-box and leucine-rich repeat protein 8 Neighboring gene heat shock transcription factor 4 Neighboring gene KIAA0895-like Neighboring gene exocyst complex component 3-like 1 Neighboring gene E2F transcription factor 4, p107/p130-binding

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of nucleolar protein 3, apoptosis repressor with CARD domain (NOL3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
PubMed 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
sarcoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
nucleolar protein 3
Names
nucleolar protein 3
nucleolar protein of 30 kDa
muscle-enriched cytoplasmic protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029566.1 

    Range
    4996..10239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001185057.2NP_001171986.1  nucleolar protein 3 isoform Nop30

    See proteins identical to NP_001171986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) originates from a different promoter, has a shorter 5' UTR, and uses an alternate splice site in the CDS, compared to variant 1. This transcript and protein were described by Stoss et al. (PMID: 10196175). The resulting protein (Nop30) has the same N-terminus and then is frameshifted resulting in a distinct C-terminus, compared to isoform MYP.
    Source sequence(s)
    AF064599, DA928396
    Consensus CDS
    CCDS58473.1
    UniProtKB/Swiss-Prot
    O60936
    Related
    ENSP00000454598, OTTHUMP00000250302, ENST00000568146, OTTHUMT00000422746
    Conserved Domains (2) summary
    pfam00906
    Location:115167
    Blast Score: 81
    Hepatitis_core; Hepatitis core antigen
    cd01671
    Location:1283
    Blast Score: 89
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
  2. NM_001276307.1NP_001263236.1  nucleolar protein 3 isoform MYP

    See proteins identical to NP_001263236.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AF064599, CB959673
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    O60936
    UniProtKB/TrEMBL
    Q5TZN6
    Conserved Domains (1) summary
    cd01671
    Location:1283
    Blast Score: 87
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
  3. NM_001276309.1NP_001263238.1  nucleolar protein 3 isoform MYP

    See proteins identical to NP_001263238.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AF064599, BP215200, CB959673
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    O60936
    UniProtKB/TrEMBL
    Q5TZN6
    Conserved Domains (1) summary
    cd01671
    Location:1283
    Blast Score: 87
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
  4. NM_001276311.1NP_001263240.1  nucleolar protein 3 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the CDS compared to variant 1. The resulting protein has the same N-terminus and then is frame-shifted resulting in a distinct C-terminus, compared to isoform MYP.
    Source sequence(s)
    AF064599, BF568452, DA928396
    UniProtKB/Swiss-Prot
    O60936
    Conserved Domains (1) summary
    cd01671
    Location:1258
    Blast Score: 89
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
  5. NM_001276312.1NP_001263241.1  nucleolar protein 3 isoform MYP

    See proteins identical to NP_001263241.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform. Variants 1, 2, 4, and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AC074143, AF064599, AK294145, CB959673
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    O60936
    UniProtKB/TrEMBL
    Q5TZN6
    Related
    ENSP00000399831, ENST00000432069
    Conserved Domains (1) summary
    cd01671
    Location:1283
    Blast Score: 87
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
  6. NM_001276319.1NP_001263248.1  nucleolar protein 3 isoform D

    See proteins identical to NP_001263248.1

    Status: INFERRED

    Description
    Transcript Variant: This variant (7) is identical to variant 1 but represents possible translation from an upstream in-frame AUG codon which has a weak Kozak signal strength. The resulting isoform (D) has a longer and distinct N-terminus compared to isoform MYP. This protein product is inferred but is supported by conservation in some primate species.
    Source sequence(s)
    AC074143, AF064599, AK294145, CB959673
    Consensus CDS
    CCDS61960.1
    UniProtKB/Swiss-Prot
    O60936
    Related
    ENSP00000457243, OTTHUMP00000250300, ENST00000564053, OTTHUMT00000422740
    Conserved Domains (1) summary
    cd01671
    Location:74145
    Blast Score: 87
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
  7. NM_003946.6NP_003937.1  nucleolar protein 3 isoform MYP

    See proteins identical to NP_003937.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) originates from a different promoter and has a shorter 5' UTR, compared to variant 1. This transcript and protein were described by Stoss et al. (PMID: 10196175). Variants 1, 2, 4 and 5 encode the same protein (isoform MYP).
    Source sequence(s)
    AF064599, BQ685512
    Consensus CDS
    CCDS42176.1
    UniProtKB/Swiss-Prot
    O60936
    UniProtKB/TrEMBL
    Q5TZN6
    Related
    ENSP00000268605, ENST00000268605
    Conserved Domains (1) summary
    cd01671
    Location:1283
    Blast Score: 87
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    67170497..67175737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721323.1XP_006721386.1  

    Conserved Domains (2) summary
    pfam00906
    Location:115167
    Blast Score: 83
    Hepatitis_core; Hepatitis core antigen
    cd01671
    Location:1283
    Blast Score: 90
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
  2. XM_006721322.1XP_006721385.1  

    See proteins identical to XP_006721385.1

    UniProtKB/Swiss-Prot
    O60936
    Conserved Domains (1) summary
    cd01671
    Location:74145
    Blast Score: 87
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
  3. XM_005256217.1XP_005256274.1  

    Conserved Domains (2) summary
    pfam00906
    Location:177229
    Blast Score: 81
    Hepatitis_core; Hepatitis core antigen
    cd01671
    Location:74145
    Blast Score: 88
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
  4. XM_005256219.2XP_005256276.1  

    Conserved Domains (1) summary
    cd01671
    Location:74120
    Blast Score: 90
    CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    53077589..53082828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    68611732..68616967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001185058.1: Suppressed sequence

    Description
    NM_001185058.1: This RefSeq has been replaced by NM_001276312.1.

Supplemental Content

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