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HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [ Homo sapiens (human) ]

Gene ID: 3357, updated on 11-Sep-2014
Official Symbol
HTR2Bprovided by HGNC
Official Full Name
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupledprovided by HGNC
Primary source
HGNC:HGNC:5294
See related
Ensembl:ENSG00000135914; HPRD:03077; MIM:601122; Vega:OTTHUMG00000133222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5-HT2B; 5-HT(2B)
Summary
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]
See HTR2B in Epigenomics, MapViewer
Location:
2q36.3-q37.1
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (231108230..231125213, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231972944..231989926, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 3 Neighboring gene chromosome 2 open reading frame 72 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 Neighboring gene armadillo repeat containing 9 Neighboring gene ribosomal protein S28 pseudogene 4 Neighboring gene microRNA 4777

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog
  • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Gap junction, organism-specific biosystem (from KEGG)
    Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gap junction, conserved biosystem (from KEGG)
    Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
    Monoamine GPCRs, organism-specific biosystem
    Monoamine GPCRs
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
  • Serotonin Receptor 2 and ELK-SRF/GATA4 signaling, organism-specific biosystem (from WikiPathways)
    Serotonin Receptor 2 and ELK-SRF/GATA4 signaling, organism-specific biosystemThis pathway is courtesy of Ariadne Genomics Pathway Studio.
  • Serotonin receptors, organism-specific biosystem (from REACTOME)
    Serotonin receptors, organism-specific biosystemSerotonin (5-HT) is a monoamine neurotransmitter that plays an important role as a modulator of anger, aggression, body temperature, mood, sleep, sexuality, appetite, metabolism, as well as stimulati...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein alpha-subunit binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Ras GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
serotonin binding IDA
Inferred from Direct Assay
more info
PubMed 
serotonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
G-protein coupled receptor internalization IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
behavior IEA
Inferred from Electronic Annotation
more info
 
cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle hypertrophy ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
heart morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
intestine smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
 
neural crest cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
neural crest cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Ras GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
 
protein kinase C-activating G-protein coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of behavior IMP
Inferred from Mutant Phenotype
more info
 
release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
serotonin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
5-hydroxytryptamine receptor 2B
Names
5-hydroxytryptamine receptor 2B
5-HT-2B
5-HT 2B receptor
serotonin receptor 2B
5-hydroxytryptamine 2B receptor
5-hydroxytryptamine receptor 2B variant b

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000867.4NP_000858.3  5-hydroxytryptamine receptor 2B

    See proteins identical to NP_000858.3

    Status: VALIDATED

    Source sequence(s)
    BC063123, X77307
    Consensus CDS
    CCDS2483.1
    UniProtKB/Swiss-Prot
    P41595
    Related
    ENSP00000258400, OTTHUMP00000164294, ENST00000258400, OTTHUMT00000256957
    Conserved Domains (2) summary
    pfam00001
    Location:77380
    Blast Score: 457
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:72188
    Blast Score: 94
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    231108230..231125213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712482.1XP_006712545.1  

    Conserved Domains (2) summary
    pfam00001
    Location:52355
    Blast Score: 459
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:47163
    Blast Score: 94
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
  2. XM_005246520.2XP_005246577.1  

    Conserved Domains (1) summary
    pfam00001
    Location:2261
    Blast Score: 355
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    223815006..223831883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    231978806..231995681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)