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    RHOC ras homolog family member C [ Homo sapiens (human) ]

    Gene ID: 389, updated on 22-Sep-2016
    Official Symbol
    RHOCprovided by HGNC
    Official Full Name
    ras homolog family member Cprovided by HGNC
    Primary source
    HGNC:HGNC:669
    See related
    Ensembl:ENSG00000155366 HPRD:01322; MIM:165380; Vega:OTTHUMG00000011905
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H9; ARH9; ARHC; RHOH9
    Summary
    This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1p13.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (112701127..112707403, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113243749..113250025, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line alpha subunit 1 Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene uncharacterized LOC105378910 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1J

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with ras homolog gene family, member C (RHOC) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with ras homolog gene family, member C (RHOC) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
    • RHO GTPases Activate ROCKs, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate ROCKs, organism-specific biosystemRHO associated, coiled-coil containing protein kinases ROCK1 and ROCK2 consist of a serine/threonine kinase domain, a coiled-coil region, a RHO-binding domain and a plekstrin homology (PH) domain int...
    • RHO GTPases Activate Rhotekin and Rhophilins, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate Rhotekin and Rhophilins, organism-specific biosystemRhotekin (RTKN) is a protein with an N-terminally located RHO GTPase binding domain, that shares a limited sequence homology with PKNs and rhophilins. RTKN binds to GTP-bound RHOA, RHOB and RHOC and ...
    • RHO GTPases activate CIT, organism-specific biosystem (from REACTOME)
      RHO GTPases activate CIT, organism-specific biosystemCitron kinase (CIT) or citron RHO-interacting kinase (CRIK) shares similarities with ROCK kinases. Like ROCK, it consists of a serine/threonine kinase domain, a coiled-coil region, a RHO-binding doma...
    • RHO GTPases activate PKNs, organism-specific biosystem (from REACTOME)
      RHO GTPases activate PKNs, organism-specific biosystemProtein kinases N (PKN), also known as protein kinase C-related kinases (PKR) feature a C-terminal serine/threonine kinase domain and three RHO-binding motifs at the N-terminus. RHO GTPases RHOA, RHO...
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
      Sema4D in semaphorin signaling, organism-specific biosystemSemaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cyste...
    • Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
      Sema4D induced cell migration and growth-cone collapse, organism-specific biosystemSema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates ML...
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signaling events mediated by PRL, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PRL, organism-specific biosystem
      Signaling events mediated by PRL
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: PPM1J

    Homology

    Clone Names

    • MGC1448, MGC61427

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    apical junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokinesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    skeletal muscle satellite cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing, spreading of cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    rho-related GTP-binding protein RhoC
    Names
    RAS-related homolog 9
    oncogene RHO H9
    ras homolog gene family, member C
    rho cDNA clone 9
    rhoC GTPase
    small GTP binding protein RhoC

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042678.1NP_001036143.1  rho-related GTP-binding protein RhoC precursor

      See identical proteins and their annotated locations for NP_001036143.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      BC052808, CB851337, CX872299
      Consensus CDS
      CCDS854.1
      UniProtKB/Swiss-Prot
      P08134
      UniProtKB/TrEMBL
      A0A024R0I3
      Related
      ENSP00000358656, OTTHUMP00000013676, ENST00000369642, OTTHUMT00000032905
      Conserved Domains (2) summary
      smart00174
      Location:8180
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    2. NM_001042679.1NP_001036144.1  rho-related GTP-binding protein RhoC precursor

      See identical proteins and their annotated locations for NP_001036144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      BC009177, BQ231012, CB851337, CN289691
      Consensus CDS
      CCDS854.1
      UniProtKB/Swiss-Prot
      P08134
      UniProtKB/TrEMBL
      A0A024R0I3
      Related
      ENSP00000358647, ENST00000369633
      Conserved Domains (2) summary
      smart00174
      Location:8180
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    3. NM_175744.4NP_786886.1  rho-related GTP-binding protein RhoC precursor

      See identical proteins and their annotated locations for NP_786886.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      BC009177, CB851337, CX872299
      Consensus CDS
      CCDS854.1
      UniProtKB/Swiss-Prot
      P08134
      UniProtKB/TrEMBL
      A0A024R0I3
      Related
      ENSP00000345236, OTTHUMP00000013675, ENST00000339083, OTTHUMT00000032903
      Conserved Domains (2) summary
      smart00174
      Location:8180
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      112701127..112707403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      113358995..113365227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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