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WNT16 wingless-type MMTV integration site family, member 16 [ Homo sapiens (human) ]

Gene ID: 51384, updated on 15-Sep-2014
Official Symbol
WNT16provided by HGNC
Official Full Name
wingless-type MMTV integration site family, member 16provided by HGNC
Primary source
HGNC:HGNC:16267
See related
Ensembl:ENSG00000002745; HPRD:05882; MIM:606267; Vega:OTTHUMG00000156963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]
See WNT16 in Epigenomics, MapViewer
Location:
7q31
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (121325367..121341104)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (120965421..120981158)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cadherin-like and PC-esterase domain containing 1 Neighboring gene RNA, 5S ribosomal pseudogene 241 Neighboring gene uncharacterized LOC102724514 Neighboring gene family with sequence similarity 3, member C Neighboring gene cytochrome c, somatic pseudogene 19

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.
NHGRI GWA Catalog
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
NHGRI GWA Catalog
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.
NHGRI GWA Catalog
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
bone remodeling IEA
Inferred from Electronic Annotation
more info
 
cardiac epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
optic cup formation involved in camera-type eye development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
oxidative stress-induced premature senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
replicative senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein Wnt-16
Names
protein Wnt-16
wingless-type MMTV integration site family member 16b

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029242.1 

    Range
    5001..20738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016087.2NP_057171.2  protein Wnt-16 isoform 2

    See proteins identical to NP_057171.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs from variant 1 at the 5' terminus including 5' UTR and the coding region for the N-terminus. It encodes a shorter isoform than variant 1.
    Source sequence(s)
    AF152584, AF169963
    Consensus CDS
    CCDS5780.1
    UniProtKB/TrEMBL
    E9PH60
    UniProtKB/Swiss-Prot
    Q9UBV4
    Conserved Domains (1) summary
    pfam00110
    Location:37355
    wnt; wnt family
  2. NM_057168.1NP_476509.1  protein Wnt-16 isoform 1 precursor

    See proteins identical to NP_476509.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs from variant 2 at the 5' terminus including 5' UTR and the coding region for the N-terminus. Isoform 1, encoded by this variant, is 90% identical to the mouse Wnt16 protein at the amino acid level.
    Source sequence(s)
    AF169963
    Consensus CDS
    CCDS5781.1
    UniProtKB/Swiss-Prot
    Q9UBV4
    Related
    ENSP00000222462, OTTHUMP00000211164, ENST00000222462, OTTHUMT00000346843
    Conserved Domains (1) summary
    pfam00110
    Location:47365
    wnt; wnt family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    121325367..121341104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    115328649..115344394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    120898727..120914470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)