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    HDAC1 histone deacetylase 1 [ Homo sapiens (human) ]

    Gene ID: 3065, updated on 30-Jun-2015
    Official Symbol
    HDAC1provided by HGNC
    Official Full Name
    histone deacetylase 1provided by HGNC
    Primary source
    HGNC:HGNC:4852
    See related
    Ensembl:ENSG00000116478; HPRD:03143; MIM:601241; Vega:OTTHUMG00000007529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HD1; RPD3; GON-10; RPD3L1
    Summary
    Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
    Orthologs
    See HDAC1 in Epigenomics, MapViewer
    Location:
    1p34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (32292107..32333628)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32757708..32799227)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 167, member B Neighboring gene LCK proto-oncogene, Src family tyrosine kinase Neighboring gene MARCKS-like 1 Neighboring gene uncharacterized LOC105378629

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of histone deacetylase 1 (HDAC1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat YY1 and LSF transcription factors cooperatively recruit histone deacetylase 1 (HDAC1) to the HIV-1 LTR promoter, thereby inhibiting transcription and Tat activation of the promoter PubMed
    tat A compound in curry known as Curcumin inhibits HIV-1 Tat-mediated long terminal repeat transactivation by reversing Tat-induced dissociation of HDAC1 from LTR and by reducing the binding of p65/NFKappaB to LTR PubMed
    tat The SIN3/HDAC complex, composed of SIN3A, SAP30, SAP18, HDAC-1 AND -2 and RbAp46/48 except SAP30, are identified to interact with HIV-1 Tat in Jurkat cell PubMed
    Vpr vpr COUP-TF-interacting protein 2 (CTIP2) abolishes Vpr-mediated stimulation of p21 by cooperating with SUV39H1 and HDAC1/HDAC2 to silence the p21 gene transcription PubMed
    integrase gag-pol KAP1 inhibits HIV-1 integration via HIV-1 IN acetylation-dependent mechanism by inducing IN/HDAC1 complex formation PubMed
    gag-pol HIV-1 IN and INI1/hSNF5 bind SAP18 and selectively recruit components of Sin3a-HDAC1 complex into HIV-1 virions. HIV-1 virion-associated HDAC1 is required for efficient early post-entry events PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • DKFZp686H12203

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    NF-kappaB binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone deacetylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to nucleosomal DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein N-terminus binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    ATP-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Notch signaling pathway TAS
    Traceable Author Statement
    more info
     
    blood coagulation TAS
    Traceable Author Statement
    more info
     
    chromatin modification TAS
    Traceable Author Statement
    more info
    PubMed 
    chromatin organization TAS
    Traceable Author Statement
    more info
     
    chromatin remodeling IC
    Inferred by Curator
    more info
    PubMed 
    circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    embryonic digit morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    epidermal cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    eyelid development in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fungiform papilla formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    gene expression TAS
    Traceable Author Statement
    more info
     
    hair follicle placode formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    histone H3 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H4 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    negative regulation by host of viral transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell cycle TAS
    Traceable Author Statement
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression, epigenetic TAS
    Traceable Author Statement
    more info
     
    NOT negative regulation of myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neurotrophin TRK receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    odontogenesis of dentin-containing tooth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression, epigenetic TAS
    Traceable Author Statement
    more info
     
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    transcription, DNA-templated TAS
    Traceable Author Statement
    more info
     
    transforming growth factor beta receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    NuRD complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Sin3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    histone deacetylase 1
    Names
    reduced potassium dependency, yeast homolog-like 1
    NP_004955.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004964.2NP_004955.2  histone deacetylase 1

      See identical proteins and their annotated locations for NP_004955.2

      Status: REVIEWED

      Source sequence(s)
      D50405
      Consensus CDS
      CCDS360.1
      UniProtKB/Swiss-Prot
      Q13547
      UniProtKB/TrEMBL
      Q6IT96
      Related
      ENSP00000362649, OTTHUMP00000008745, ENST00000373548, OTTHUMT00000019815
      Conserved Domains (1) summary
      cd10010
      Location:4374
      HDAC1; Histone deacetylase 1 (HDAC1)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      32292107..32333628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541309.1XP_011539611.1  

      Conserved Domains (1) summary
      cl17011
      Location:1181
      Arginase_HDAC; Arginase-like and histone-like hydrolases

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      32873153..32914668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)