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    GOLGA3 golgin A3 [ Homo sapiens (human) ]

    Gene ID: 2802, updated on 17-Sep-2016
    Official Symbol
    GOLGA3provided by HGNC
    Official Full Name
    golgin A3provided by HGNC
    Primary source
    HGNC:HGNC:4426
    See related
    Ensembl:ENSG00000090615 Ensembl:ENSG00000283396 HPRD:03990; MIM:602581; Vega:OTTHUMG00000168023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEA-2; GCP170
    Summary
    The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]
    Orthologs
    Location:
    12q24.33
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (132768909..132829131, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133345495..133405659, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 379 Neighboring gene ankyrin repeat and LEM domain containing 2 Neighboring gene tumor protein D52 like 2 pseudogene Neighboring gene ribosomal protein S11 pseudogene 5 Neighboring gene RNA, U6 small nuclear 327, pseudogene Neighboring gene checkpoint with forkhead and ring finger domains

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of antibody response to smallpox vaccine.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding involved in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transporter activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    intra-Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    golgin subfamily A member 3
    Names
    Golgi membrane associated protein
    Golgi peripheral membrane protein
    SY2/SY10 protein
    golgi autoantigen, golgin subfamily a, 3
    golgi complex-associated protein of 170 kDa
    golgin-160
    golgin-165
    male enhanced antigen-2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029887.1 RefSeqGene

      Range
      5001..64932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001172557.1NP_001166028.1  golgin subfamily A member 3 isoform 2

      See identical proteins and their annotated locations for NP_001166028.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR and contains a different 3' end, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC127070, BC146675, D63997
      Consensus CDS
      CCDS53846.1
      UniProtKB/Swiss-Prot
      Q08378
      Related
      ENSP00000442603, ENST00000545875
      Conserved Domains (2) summary
      pfam05010
      Location:812997
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl19219
      Location:812886
      DUF342; Protein of unknown function (DUF342)
    2. NM_005895.3NP_005886.2  golgin subfamily A member 3 isoform 1

      See identical proteins and their annotated locations for NP_005886.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC127070, AC136467, AF485338, BC060826, BF902971, BM842318, BQ898615, D63997
      Consensus CDS
      CCDS9281.1
      UniProtKB/Swiss-Prot
      Q08378
      Related
      ENSP00000204726, ENST00000204726
      Conserved Domains (2) summary
      pfam05010
      Location:812997
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl19219
      Location:812886
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      132768909..132829131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006719737.3XP_006719800.1  

      See identical proteins and their annotated locations for XP_006719800.1

      UniProtKB/Swiss-Prot
      Q08378
      Conserved Domains (2) summary
      pfam05010
      Location:812997
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl19219
      Location:812886
      DUF342; Protein of unknown function (DUF342)
    2. XM_011534793.2XP_011533095.1  

      Conserved Domains (3) summary
      PRK03918
      Location:7781268
      PRK03918; chromosome segregation protein; Provisional
      pfam05010
      Location:721906
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl19219
      Location:721795
      DUF342; Protein of unknown function (DUF342)
    3. XM_005266164.4XP_005266221.1  

      See identical proteins and their annotated locations for XP_005266221.1

      Conserved Domains (2) summary
      pfam05010
      Location:772957
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl19219
      Location:772846
      DUF342; Protein of unknown function (DUF342)
    4. XM_006719736.3XP_006719799.1  

      See identical proteins and their annotated locations for XP_006719799.1

      UniProtKB/Swiss-Prot
      Q08378
      Related
      ENSP00000410378, OTTHUMP00000237617, ENST00000450791, OTTHUMT00000397569
      Conserved Domains (2) summary
      pfam05010
      Location:812997
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl19219
      Location:812886
      DUF342; Protein of unknown function (DUF342)
    5. XM_005266167.4XP_005266224.1  

      Conserved Domains (2) summary
      COG1196
      Location:4391167
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl19219
      Location:621695
      DUF342; Protein of unknown function (DUF342)
    6. XM_011534794.2XP_011533096.1  

      Conserved Domains (2) summary
      cl19219
      Location:164247
      DUF342; Protein of unknown function (DUF342)
      TIGR02168
      Location:20694
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      133165472..133225444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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