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    Pten phosphatase and tensin homolog [ Mus musculus (house mouse) ]

    Gene ID: 19211, updated on 23-Aug-2016
    Official Symbol
    Ptenprovided by MGI
    Official Full Name
    phosphatase and tensin homologprovided by MGI
    Primary source
    MGI:MGI:109583
    See related
    Ensembl:ENSMUSG00000013663 Vega:OTTMUSG00000021203
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TEP1; MMAC1; AI463227; 2310035O07Rik; A130070J02Rik; B430203M17Rik
    Summary
    This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    19 C1; 19 28.14 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (32757577..32826160)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (32832067..32900650)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene ATPase family, AAA domain containing 1 Neighboring gene predicted gene, 36566 Neighboring gene predicted gene, 36774 Neighboring gene predicted gene, 36914 Neighboring gene predicted gene, 36860

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC183880

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    anaphase-promoting complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to decreased oxygen levels IDA
    Inferred from Direct Assay
    more info
     
    cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
     
    central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system myelin maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dentate gyrus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inositol phosphate dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long term synaptic depression ISO
    Inferred from Sequence Orthology
    more info
     
    long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maternal behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organismal response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cardiac muscle cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of synaptic vesicle clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron-neuron synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of TRAIL-activated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prepulse inhibition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    presynaptic membrane assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostate gland growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of B cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of axon regeneration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cellular component size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cellular localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of myeloid cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
     
    rhythmic synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Schmidt-Lanterman incisure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath adaxonal region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Names
    mitochondrial PTENalpha
    mutated in multiple advanced cancers 1
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    NP_032986.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008960.2NP_032986.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

      See identical proteins and their annotated locations for NP_032986.1

      Status: REVIEWED

      Source sequence(s)
      AK138025, BU701098, CK616227, U92437
      Consensus CDS
      CCDS29753.1
      UniProtKB/Swiss-Prot
      O08586
      UniProtKB/TrEMBL
      Q3UUT8
      Related
      ENSMUSP00000013807, OTTMUSP00000023423, ENSMUST00000013807, OTTMUST00000050229
      Conserved Domains (2) summary
      smart00404
      Location:92183
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      pfam10409
      Location:188349
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      32757577..32826160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526769.2XP_006526832.1  

      Conserved Domains (1) summary
      pfam10409
      Location:55216
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177096.2: Suppressed sequence

      Description
      NM_177096.2: This RefSeq was temporarily suppressed because it is suspected to be 3' UTR sequence of a splice variant of the Pten gene (GeneID:19211).