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SIR3 chromatin-silencing protein SIR3 [ Saccharomyces cerevisiae S288c ]

Gene ID: 851163, updated on 22-Mar-2015
Gene symbol
SIR3
Gene description
chromatin-silencing protein SIR3
Primary source
SGD:S000004434
Locus tag
YLR442C
Gene type
protein coding
RNA name
chromatin-silencing protein SIR3
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CMT1; MAR2; STE8
See SIR3 in MapViewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (1019315..1022251, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Sec39p Neighboring gene ribosomal 40S subunit protein S1A Neighboring gene Ecm7p Neighboring gene Gmc2p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleosomal histone binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear telomeric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
chromatin-silencing protein SIR3
NP_013547.3
  • Silencing protein; interacts with Sir2p, Sir4p, and histone H3 and H4 tails to establish transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus (residues 840-978) assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; SIR3 has a paralog, ORC1, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1019315..1022251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182330.3NP_013547.3  chromatin-silencing protein SIR3 [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_013547.3

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P06701
    Conserved Domains (2) summary
    COG1474
    Location:528962
    CDC6; Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]
    cd04720
    Location:5189
    BAH_Orc1p_Yeast; BAH, or Bromo Adjacent Homology domain, as present in Orc1p, which again is part of the Saccharomyces cerevisiae Sir1-origin recognition complex, and as present in Sir3p. The Orc1p BAH doman functions in epigenetic silencing. BAH domains are found in a ...