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    LIN28A lin-28 homolog A [ Homo sapiens (human) ]

    Gene ID: 79727, updated on 9-Jun-2016
    Official Symbol
    LIN28Aprovided by HGNC
    Official Full Name
    lin-28 homolog Aprovided by HGNC
    Primary source
    HGNC:HGNC:15986
    See related
    Ensembl:ENSG00000131914 HPRD:17278; MIM:611043; Vega:OTTHUMG00000003550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A
    Summary
    This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    1p36.11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (26410768..26429728)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26737269..26756219)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene absent in melanoma 1-like Neighboring gene ribosomal protein L34 pseudogene 4 Neighboring gene zinc finger protein 683 Neighboring gene dehydrodolichyl diphosphate synthase subunit Neighboring gene uncharacterized LOC101928324 Neighboring gene ribosomal protein L17 pseudogene 9

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    NHGRI GWA Catalog
    • Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
      Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Transcriptional regulation of pluripotent stem cells, organism-specific biosystem (from REACTOME)
      Transcriptional regulation of pluripotent stem cells, organism-specific biosystemPluripotent stem cells are undifferentiated cells posessing an abbreviated cell cycle (reviewed in Stein et al. 2012), a characteristic profile of gene expression (Rao et al. 2004, Kim et al. 2006, P...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ12457

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation initiation factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ cell development IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation involved in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    pre-miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene silencing by miRNA IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    somatic stem cell population maintenance TAS
    Traceable Author Statement
    more info
     
    stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic mRNA processing body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    protein lin-28 homolog A
    Names
    RNA-binding protein LIN-28
    zinc finger CCHC domain-containing protein 1
    zinc finger, CCHC domain containing 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024674.5NP_078950.1  protein lin-28 homolog A

      See identical proteins and their annotated locations for NP_078950.1

      Status: REVIEWED

      Source sequence(s)
      AL513365, BC028566, CN349325
      Consensus CDS
      CCDS280.1
      UniProtKB/Swiss-Prot
      Q9H9Z2
      Related
      ENSP00000363314, OTTHUMP00000003663, ENST00000326279, OTTHUMT00000009891
      Conserved Domains (1) summary
      cd04458
      Location:42111
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      26410768..26429728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542148.1XP_011540450.1  

      See identical proteins and their annotated locations for XP_011540450.1

      UniProtKB/Swiss-Prot
      Q9H9Z2
      Conserved Domains (1) summary
      cd04458
      Location:42111
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      26850263..26869222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)