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SLC17A1 solute carrier family 17 (organic anion transporter), member 1 [ Homo sapiens (human) ]

Gene ID: 6568, updated on 11-Dec-2014
Official Symbol
SLC17A1provided by HGNC
Official Full Name
solute carrier family 17 (organic anion transporter), member 1provided by HGNC
Primary source
HGNC:HGNC:10929
See related
Ensembl:ENSG00000124568; HPRD:01661; MIM:182308; Vega:OTTHUMG00000016297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPT1; NPT-1; NAPI-1
See SLC17A1 in Epigenomics, MapViewer
Location:
6p22.2
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (25782897..25832059, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (25783125..25832287, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene histone cluster 1, H2a, pseudogene 1 Neighboring gene solute carrier family 17, member 4 Neighboring gene solute carrier family 17 (organic anion transporter), member 3 Neighboring gene histone cluster 1, H2a, pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of red blood cell traits using the electronic medical record.
NHGRI GWA Catalog
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Common variants on chromosome 6p22.1 are associated with schizophrenia.
NHGRI GWA Catalog
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog
Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.
NHGRI GWA Catalog
Identification of low-frequency variants associated with gout and serum uric acid levels.
NHGRI GWA Catalog
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
NHGRI GWA Catalog
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
NHGRI GWA Catalog
Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.
NHGRI GWA Catalog
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126794, MGC126796

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sodium-dependent phosphate transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ion transport TAS
Traceable Author Statement
more info
 
phosphate ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
phosphate ion transport TAS
Traceable Author Statement
more info
PubMed 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
sodium-dependent phosphate transport TAS
Traceable Author Statement
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
urate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
sodium-dependent phosphate transport protein 1
Names
sodium-dependent phosphate transport protein 1
na/Pi-4
Na(+)/PI cotransporter 1
sodium phosphate transporter
sodium/phosphate cotransporter 1
solute carrier family 17 member 1
sodium/phosphate type I cotransporter
renal sodium-phosphate transport protein 1
renal Na(+)-dependent phosphate cotransporter 1
renal sodium-dependent phosphate transport protein 1
solute carrier family 17 (sodium phosphate), member 1
solute carrier family 17 (vesicular glutamate transporter), member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005074.3NP_005065.2  sodium-dependent phosphate transport protein 1

    See proteins identical to NP_005065.2

    Status: VALIDATED

    Source sequence(s)
    BC101745, BG054690, D28532, DC362172
    Consensus CDS
    CCDS4565.1
    UniProtKB/Swiss-Prot
    Q14916
    Related
    ENSP00000244527, OTTHUMP00000017909, ENST00000244527, OTTHUMT00000043647
    Conserved Domains (2) summary
    cd06174
    Location:73451
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:3466
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    25782897..25832059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249306.2XP_005249363.1  

    See proteins identical to XP_005249363.1

    Conserved Domains (2) summary
    cd06174
    Location:90468
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:20483
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
  2. XM_005249307.2XP_005249364.1  

    See proteins identical to XP_005249364.1

    Related
    ENSP00000420614, OTTHUMP00000214413, ENST00000476801, OTTHUMT00000353946
    Conserved Domains (2) summary
    cd06174
    Location:90468
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00894
    Location:20483
    2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    25785355..25834494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    25726038..25775499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)