Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    Trim24 tripartite motif-containing 24 [ Mus musculus (house mouse) ]

    Gene ID: 21848, updated on 27-Jun-2015
    Official Symbol
    Trim24provided by MGI
    Official Full Name
    tripartite motif-containing 24provided by MGI
    Primary source
    MGI:MGI:109275
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TIF1; Tif1a; AI447469; TIF1alpha; TIF1-alpha; A130082H20Rik; D430004I05Rik
    Summary
    The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
    Orthologs
    See Trim24 in Epigenomics, MapViewer
    Location:
    6; 6 B1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (37869880..37968445)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (37820811..37916292)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 2 Neighboring gene general transcription factor IIB pseudogene Neighboring gene SV2 related protein homolog (rat)-like Neighboring gene vomeronasal 2, receptor 121 pseudogene Neighboring gene predicted gene, 33494

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    coenzyme F420-0 gamma-glutamyl ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    coenzyme F420-2 alpha-glutamyl ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    estrogen response element binding ISO
    Inferred from Sequence Orthology
    more info
     
    ligand-dependent nuclear receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity, elongating IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity, initiating IEA
    Inferred from Electronic Annotation
    more info
     
    ribosomal S6-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    tubulin-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to estrogen stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of nucleic acid-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of signal transduction by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vitamin D receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perichromatin fibrils IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    transcription intermediary factor 1-alpha
    Names
    transcription intermediary factor 1-alpha
    E3 ubiquitin-protein ligase Trim24
    transcriptional intermediary factor 1, alpha
    tripartite motif-containing protein 24

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272064.1NP_001258993.1  transcription intermediary factor 1-alpha isoform 2

      See identical proteins and their annotated locations for NP_001258993.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame donor splice site in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC113501, S78219
      Consensus CDS
      CCDS71751.1
      UniProtKB/Swiss-Prot
      Q64127
      Conserved Domains (6) summary
      cd05502
      Location:867974
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:266392
      BBC; B-Box C-terminal domain
      smart00336
      Location:158194
      BBOX; B-Box-type zinc finger
      cd00021
      Location:221259
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:5178
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15624
      Location:795840
      PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
    2. NM_001272076.1NP_001259005.1  transcription intermediary factor 1-alpha isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus that lacks the N-terminal RING domain, compared to isoform 1.
      Source sequence(s)
      AC113501, AK133144, S78219
      Consensus CDS
      CCDS71752.1
      UniProtKB/TrEMBL
      E9Q1U8
      UniProtKB/TrEMBL
      Q3V0H4
      UniProtKB/Swiss-Prot
      Q64127
      Conserved Domains (6) summary
      cd05502
      Location:831938
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:196322
      BBC; B-Box C-terminal domain
      smart00336
      Location:88124
      BBOX; B-Box-type zinc finger
      cd00021
      Location:151189
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam00628
      Location:759802
      PHD; PHD-finger
      pfam14179
      Location:417482
      YppG; YppG-like protein
    3. NM_145076.4NP_659542.3  transcription intermediary factor 1-alpha isoform 1

      See identical proteins and their annotated locations for NP_659542.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC113501, S78221
      Consensus CDS
      CCDS20008.1
      UniProtKB/Swiss-Prot
      Q64127
      Conserved Domains (6) summary
      cd05502
      Location:9011008
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:266392
      BBC; B-Box C-terminal domain
      smart00336
      Location:158194
      BBOX; B-Box-type zinc finger
      cd00021
      Location:221259
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:5178
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
      pfam00628
      Location:829872
      PHD; PHD-finger

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

      Range
      37869880..37968445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505895.2XP_006505958.1  

      Conserved Domains (3) summary
      cd05502
      Location:624731
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:1115
      BBC; B-Box C-terminal domain
      pfam00628
      Location:552595
      PHD; PHD-finger

    Alternate Mm_Celera

    Genomic

    1. AC_000028.1 Alternate Mm_Celera

      Range
      37857341..37954866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)