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    Cd28 CD28 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12487, updated on 13-Aug-2016
    Official Symbol
    Cd28provided by MGI
    Official Full Name
    CD28 antigenprovided by MGI
    Primary source
    MGI:MGI:88327
    See related
    Ensembl:ENSMUSG00000026012 Vega:OTTMUSG00000002254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    1 30.52 cM; 1 C1-C3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (60746388..60773359)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (60803232..60830203)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38388 Neighboring gene eukaryotic translation initiation factor 4A, pseudogene 4 Neighboring gene RIKEN cDNA 2310016D23 gene Neighboring gene lactate dehydrogenase B pseudogene Neighboring gene mortality factor 4 like 2 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3/SH2 adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T cell costimulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    T cell costimulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
     
    T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of alpha-beta T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-2 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-2 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-4 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of regulatory T cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex involved in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    T-cell-specific surface glycoprotein CD28

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007642.4NP_031668.3  T-cell-specific surface glycoprotein CD28 precursor

      See identical proteins and their annotated locations for NP_031668.3

      Status: VALIDATED

      Source sequence(s)
      AK030812, AK037772, BC064058, BY225764
      Consensus CDS
      CCDS14992.1
      UniProtKB/Swiss-Prot
      P31041
      UniProtKB/TrEMBL
      Q8CDB3
      Related
      ENSMUSP00000027165, OTTMUSP00000002157, ENSMUST00000027165, OTTMUST00000004499
      Conserved Domains (1) summary
      cl11960
      Location:22137
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      60746388..60773359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 PATCHES

    Genomic

    1. NW_006763128.1 Reference GRCm38.p4 PATCHES

      Range
      50473..77469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187019.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      98742..125738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)