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    Ndfip1 Nedd4 family interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 65113, updated on 8-Aug-2016
    Official Symbol
    Ndfip1provided by MGI
    Official Full Name
    Nedd4 family interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1929601
    See related
    Ensembl:ENSMUSG00000024425
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N4wbp5; 0610010M22Rik
    Orthologs
    Location:
    18; 18 B3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (38418912..38465190)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (38578629..38624060)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41703 Neighboring gene glutamate-ammonia ligase (glutamine synthetase) pseudogene Neighboring gene predicted gene, 41704 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    WW domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-4 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of isotype switching to IgE isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of type 2 immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of lymphocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of myeloid leukocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of Golgi membrane IC
    Inferred by Curator
    more info
    PubMed 
    integral component of membrane ISM
    Inferred from Sequence Model
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    NEDD4 family-interacting protein 1
    Names
    NEDD4 WW domain-binding protein 5
    Nedd4 WW binding protein 5
    Nedd4 WW-binding protein 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022996.1NP_075372.1  NEDD4 family-interacting protein 1

      See identical proteins and their annotated locations for NP_075372.1

      Status: PROVISIONAL

      Source sequence(s)
      BC026372
      Consensus CDS
      CCDS37789.1
      UniProtKB/Swiss-Prot
      Q8R0W6
      Related
      ENSMUSP00000025293, ENSMUST00000025293
      Conserved Domains (1) summary
      pfam10176
      Location:36216
      DUF2370; Protein of unknown function (DUF2370)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      38418912..38465190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526149.1XP_006526212.1  

      See identical proteins and their annotated locations for XP_006526212.1

      UniProtKB/Swiss-Prot
      Q8R0W6
      Conserved Domains (1) summary
      pfam10176
      Location:36216
      DUF2370; Protein of unknown function (DUF2370)