Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Akt1 thymoma viral proto-oncogene 1 [ Mus musculus (house mouse) ]

    Gene ID: 11651, updated on 17-Jul-2016
    Official Symbol
    Akt1provided by MGI
    Official Full Name
    thymoma viral proto-oncogene 1provided by MGI
    Primary source
    MGI:MGI:87986
    See related
    Ensembl:ENSMUSG00000001729 Vega:OTTMUSG00000020941
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Akt; PKB; Rac; PKB/Akt; PKBalpha
    Summary
    This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
    Orthologs
    Location:
    12 F1; 12 61.2 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (112653821..112674796, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (113892032..113912487, complement)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30101 Neighboring gene SIVA1, apoptosis-inducing factor Neighboring gene microRNA 6939 Neighboring gene predicted gene, 30150 Neighboring gene zinc finger and BTB domain containing 42 Neighboring gene predicted gene, 30238 Neighboring gene predicted gene, 30298

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nitric-oxide synthase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine/tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation-induced cell death of T cells ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    aging ISO
    Inferred from Sequence Orthology
    more info
     
    anagen IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic mitochondrial changes IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to decreased oxygen levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to epidermal growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to peptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to prostaglandin E stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    establishment of protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    germ cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    glycogen cell differentiation involved in embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    maintenance of protein location in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    maternal placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of plasma membrane long-chain fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peripheral nervous system myelin maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of establishment of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase B signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    response to UV-A ISO
    Inferred from Sequence Orthology
    more info
     
    response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to food IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    spinal cord development ISO
    Inferred from Sequence Orthology
    more info
     
    striated muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    translation ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    RAC-alpha serine/threonine-protein kinase
    Names
    AKT1 kinase
    Akt1m protein
    PKB alpha
    RAC-PK-alpha
    protein kinase B alpha
    protein kinase B-alpha
    proto-oncogene c-AKT
    related to A and C kinases
    NP_001159366.1
    NP_033782.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165894.1NP_001159366.1  RAC-alpha serine/threonine-protein kinase isoform 2

      See identical proteins and their annotated locations for NP_001159366.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI843381, BC066018
      UniProtKB/Swiss-Prot
      P31750
      Conserved Domains (3) summary
      smart00220
      Location:150408
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05571
      Location:154466
      STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B
    2. NM_009652.3NP_033782.1  RAC-alpha serine/threonine-protein kinase isoform 1

      See identical proteins and their annotated locations for NP_033782.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI843381, BC066018
      Consensus CDS
      CCDS26194.1
      UniProtKB/Swiss-Prot
      P31750
      Related
      ENSMUSP00000001780, OTTMUSP00000022944, ENSMUST00000001780, OTTMUST00000049495
      Conserved Domains (3) summary
      smart00220
      Location:150408
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05594
      Location:124479
      STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      112653821..112674796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515416.2XP_006515479.1  

      See identical proteins and their annotated locations for XP_006515479.1

      UniProtKB/Swiss-Prot
      P31750
      Related
      ENSMUSP00000122222, OTTMUSP00000022947, ENSMUST00000128300, OTTMUST00000049500
      Conserved Domains (3) summary
      smart00220
      Location:150408
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05594
      Location:124479
      STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)
    2. XM_006515415.1XP_006515478.1  

      See identical proteins and their annotated locations for XP_006515478.1

      UniProtKB/Swiss-Prot
      P31750
      Conserved Domains (3) summary
      smart00220
      Location:150408
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01241
      Location:4111
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05594
      Location:124479
      STKc_PKB_alpha; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1)