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MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) [ Homo sapiens (human) ]

Gene ID: 4282, updated on 15-Sep-2014
Official Symbol
MIFprovided by HGNC
Official Full Name
macrophage migration inhibitory factor (glycosylation-inhibiting factor)provided by HGNC
Primary source
HGNC:HGNC:7097
See related
HPRD:01091; MIM:153620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIF; GLIF; MMIF
Summary
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
Location:
22q11.23
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 22 NC_000022.11 (23894378..23895222)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24236565..24237409)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene derlin 3 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 11 Neighboring gene MIF antisense RNA 1 Neighboring gene kelch-like family member 5 pseudogene Neighboring gene glutathione S-transferase theta 2B (gene/pseudogene)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Rheumatoid arthritis, systemic juvenile
MedGen: C1858558 OMIM: 604302 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL-6, IL-8, MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1) PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
dopachrome isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
phenylpyruvate tautomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
carboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cell aging IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell aging IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cellular protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mature B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myeloid cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chemokine (C-X-C motif) ligand 2 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myeloid leukocyte cytokine production involved in immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of prostaglandin secretion involved in immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase A signaling IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
protein homotrimerization IPI
Inferred from Physical Interaction
more info
PubMed 
regulation of macrophage activation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
macrophage migration inhibitory factor
Names
macrophage migration inhibitory factor
L-dopachrome isomerase
L-dopachrome tautomerase
phenylpyruvate tautomerase
NP_002406.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012099.1 

    Range
    5001..5845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002415.1NP_002406.1  macrophage migration inhibitory factor

    See proteins identical to NP_002406.1

    Status: REVIEWED

    Source sequence(s)
    L19686
    Consensus CDS
    CCDS13819.1
    UniProtKB/TrEMBL
    I4AY87
    UniProtKB/Swiss-Prot
    P14174
    Conserved Domains (1) summary
    pfam01187
    Location:2115
    MIF; Macrophage migration inhibitory factor (MIF)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_187633.1 

    Range
    130740..131584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000022.11 

    Range
    23894378..23895222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000154.1 

    Range
    7221904..7222748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 

    Range
    24248957..24249801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)