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    PDYN prodynorphin [ Homo sapiens (human) ]

    Gene ID: 5173, updated on 15-Jul-2015
    Official Symbol
    PDYNprovided by HGNC
    Official Full Name
    prodynorphinprovided by HGNC
    Primary source
    HGNC:HGNC:8820
    See related
    Ensembl:ENSG00000101327; HPRD:08838; MIM:131340; Vega:OTTHUMG00000031683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADCA; PENKB; SCA23
    Summary
    The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
    Orthologs
    See PDYN in Epigenomics, MapViewer
    Location:
    20p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (1978756..1994285, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1959402..1974931, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene cytoskeleton associated protein 2-like pseudogene Neighboring gene signal-regulatory protein alpha Neighboring gene uncharacterized LOC727993 Neighboring gene ribosomal protein L7 pseudogene 2 Neighboring gene serine/threonine kinase 35

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Spinocerebellar ataxia 23
    MedGen: C1853250 OMIM: 610245 GeneReviews: Hereditary Ataxia Overview
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of antibody response to smallpox vaccine.
    NHGRI GWA Catalog
    Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study.
    NHGRI GWA Catalog
    Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
    NHGRI GWA Catalog
    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Cocaine addiction, organism-specific biosystem (from KEGG)
      Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Cocaine addiction, conserved biosystem (from KEGG)
      Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • G-protein activation, organism-specific biosystem (from REACTOME)
      G-protein activation, organism-specific biosystemReceptor activated heterotrimeric G proteins consist of the Galpha and the tightly associated Gbeta-gamma subunits. When a ligand binds to a G protein-coupled receptor, it stabilises a conformation ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Opioid Signalling, organism-specific biosystem (from REACTOME)
      Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC26418

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    opioid peptide activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    proenkephalin-B
    Names
    beta-neoendorphin-dynorphin
    leu-enkephalin
    leumorphin
    neoendorphin-dynorphin-enkephalin prepropeptide
    preprodynorphin
    preproenkephalin B
    rimorphin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028027.1 RefSeqGene

      Range
      4961..20490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190892.1NP_001177821.1  proenkephalin-B preproprotein

      See identical proteins and their annotated locations for NP_001177821.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR sequence and encodes the same protein, as compared to variant 1.
      Source sequence(s)
      AK289618, AL034562, BC026334
      Consensus CDS
      CCDS13023.1
      UniProtKB/Swiss-Prot
      P01213
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    2. NM_001190898.2NP_001177827.1  proenkephalin-B preproprotein

      See identical proteins and their annotated locations for NP_001177827.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, which results in three nt less than variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AL034562, BC026334, DA157767, DA178888, DA297229
      Consensus CDS
      CCDS13023.1
      UniProtKB/Swiss-Prot
      P01213
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    3. NM_001190899.2NP_001177828.1  proenkephalin-B preproprotein

      See identical proteins and their annotated locations for NP_001177828.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' UTR and encodes the same protein, as compared to variant 1.
      Source sequence(s)
      AL034562, BC026334, DA157767, DA178888, DA302375
      Consensus CDS
      CCDS13023.1
      UniProtKB/Swiss-Prot
      P01213
      Related
      ENSP00000440185, ENST00000539905
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    4. NM_001190900.1NP_001177829.1  proenkephalin-B preproprotein

      See identical proteins and their annotated locations for NP_001177829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 5' UTR exon, as compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AL034562, BC026334, DA305883
      Consensus CDS
      CCDS13023.1
      UniProtKB/Swiss-Prot
      P01213
      Related
      ENSP00000442259, ENST00000540134
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    5. NM_024411.4NP_077722.1  proenkephalin-B preproprotein

      See identical proteins and their annotated locations for NP_077722.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variants 2-5 encode the same protein.
      Source sequence(s)
      AL034562, BC026334, DA157767, DA178888
      Consensus CDS
      CCDS13023.1
      UniProtKB/Swiss-Prot
      P01213
      Related
      ENSP00000217305, OTTHUMP00000030002, ENST00000217305, OTTHUMT00000077569
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

      Range
      1978756..1994285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529249.1XP_011527551.1  

      See identical proteins and their annotated locations for XP_011527551.1

      UniProtKB/Swiss-Prot
      P01213
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    2. XM_011529247.1XP_011527549.1  

      See identical proteins and their annotated locations for XP_011527549.1

      UniProtKB/Swiss-Prot
      P01213
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    3. XM_011529246.1XP_011527548.1  

      See identical proteins and their annotated locations for XP_011527548.1

      UniProtKB/Swiss-Prot
      P01213
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    4. XM_011529244.1XP_011527546.1  

      See identical proteins and their annotated locations for XP_011527546.1

      UniProtKB/Swiss-Prot
      P01213
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    5. XM_011529245.1XP_011527547.1  

      See identical proteins and their annotated locations for XP_011527547.1

      UniProtKB/Swiss-Prot
      P01213
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    6. XM_011529248.1XP_011527550.1  

      See identical proteins and their annotated locations for XP_011527550.1

      UniProtKB/Swiss-Prot
      P01213
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    7. XM_011529250.1XP_011527552.1  

      See identical proteins and their annotated locations for XP_011527552.1

      UniProtKB/Swiss-Prot
      P01213
      Conserved Domains (1) summary
      pfam01160
      Location:2168
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      1959620..1975149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)