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    Itgb3 integrin beta 3 [ Mus musculus (house mouse) ]

    Gene ID: 16416, updated on 25-Jul-2016
    Official Symbol
    Itgb3provided by MGI
    Official Full Name
    integrin beta 3provided by MGI
    Primary source
    MGI:MGI:96612
    See related
    Ensembl:ENSMUSG00000020689 Vega:OTTMUSG00000003177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD61; GP3A; INGRB3
    Orthologs
    Location:
    11 E1; 11 67.84 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (104608000..104670476)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (104469314..104531787)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-14 pseudogene Neighboring gene myosin, light polypeptide 4 Neighboring gene predicted gene 7020 Neighboring gene ribosomal protein L3 pseudogene Neighboring gene EF-hand calcium binding domain 13

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC159221, MGC159223

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to C-X3-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to fibrinogen binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to insulin-like growth factor I binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to neuregulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    vascular endothelial growth factor receptor 2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis involved in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    apolipoprotein A-I-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection morphogenesis IC
    Inferred by Curator
    more info
    PubMed 
    cell-matrix adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell-substrate junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to platelet-derived growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of low-density lipoprotein particle receptor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of bone resorption IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glomerular mesangial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of osteoclast differentiation IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of G-protein coupled receptor protein signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    alpha9-beta1 integrin-ADAM8 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alphav-beta3 integrin-IGF-1-IGF1R complex ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integrin alpha9-beta1 complex TAS
    Traceable Author Statement
    more info
    PubMed 
    integrin alphav-beta3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    integrin complex ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    melanosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    integrin beta-3
    Names
    GPIIIa
    platelet gpIIIa
    platelet membrane glycoprotein IIIa

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016780.2NP_058060.2  integrin beta-3 precursor

      See identical proteins and their annotated locations for NP_058060.2

      Status: VALIDATED

      Source sequence(s)
      BC125520, BQ033439, BX000996
      Consensus CDS
      CCDS25536.1
      UniProtKB/Swiss-Prot
      O54890
      Related
      ENSMUSP00000021028, OTTMUSP00000003116, ENSMUST00000021028, OTTMUST00000006575
      Conserved Domains (3) summary
      pfam00362
      Location:37460
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:633716
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:743785
      Integrin_b_cyt; Integrin beta cytoplasmic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      104608000..104670476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532312.2XP_006532375.1  

      Conserved Domains (3) summary
      pfam08725
      Location:722767
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      pfam00362
      Location:18441
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:614698
      Integrin_B_tail; Integrin beta tail domain