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    CD5 CD5 molecule [ Homo sapiens (human) ]

    Gene ID: 921, updated on 26-Jun-2015
    Official Symbol
    CD5provided by HGNC
    Official Full Name
    CD5 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1685
    See related
    Ensembl:ENSG00000110448; HPRD:01078; MIM:153340; Vega:OTTHUMG00000167825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T1; LEU1
    Orthologs
    Location:
    11q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (61102458..61127852)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60869930..60895324)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CD6 molecule Neighboring gene uncharacterized LOC105369326 Neighboring gene uncharacterized LOC105369325 Neighboring gene uncharacterized LOC105369324 Neighboring gene vacuolar protein sorting 37 homolog C (S. cerevisiae) Neighboring gene uncharacterized LOC105369327

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef impairs the generation of a CD3epsilon(+)CD5(+) CD1a(+) T cell differentiation precursor stage that initiates a D-J rearrangement of the TCRbeta locus PubMed

    Go to the HIV-1, Human Interaction Database

    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell recognition NAS
    Non-traceable Author Statement
    more info
    PubMed 
    receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    T-cell surface glycoprotein CD5
    Names
    T-cell surface glycoprotein CD5
    CD5 antigen (p56-62)
    lymphocyte antigen T1/Leu-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014207.3NP_055022.2  T-cell surface glycoprotein CD5 precursor

      See identical proteins and their annotated locations for NP_055022.2

      Status: VALIDATED

      Source sequence(s)
      AK292698, AP000437, BC027901, DB143341, X04391
      Consensus CDS
      CCDS8000.1
      UniProtKB/Swiss-Prot
      P06127
      Related
      ENSP00000342681, OTTHUMP00000236973, ENST00000347785, OTTHUMT00000396465
      Conserved Domains (2) summary
      smart00202
      Location:36133
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:279368
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

      Range
      61102458..61127852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      60734232..60759595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)