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    Acadvl acyl-Coenzyme A dehydrogenase, very long chain [ Mus musculus (house mouse) ]

    Gene ID: 11370, updated on 24-Jun-2016
    Official Symbol
    Acadvlprovided by MGI
    Official Full Name
    acyl-Coenzyme A dehydrogenase, very long chainprovided by MGI
    Primary source
    MGI:MGI:895149
    See related
    Ensembl:ENSMUSG00000018574 Vega:OTTMUSG00000006027
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    vlcad
    Summary
    This gene encodes a homodimeric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C16- and C20-acylCoA and localizes to the inner mitochondrial membrane (unlike related acyl-CoA dehydrogenases). In mice, deficiency of this gene can cause ventricular arrhythmias as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]
    Orthologs
    Location:
    11 B2-B5; 11 42.96 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (70010183..70015428, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69823694..69828909, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene PHD finger protein 23 Neighboring gene dishevelled segment polarity protein 2 Neighboring gene microRNA 324 Neighboring gene discs, large homolog 4 (Drosophila) Neighboring gene asialoglycoprotein receptor 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    electron carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain-acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    very-long-chain-acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    very-long-chain-acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid beta-oxidation using acyl-CoA dehydrogenase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    temperature homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    very long-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    very long-chain fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    very long-chain specific acyl-CoA dehydrogenase, mitochondrial
    Names
    MVLCAD
    NP_059062.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017366.3NP_059062.1  very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_059062.1

      Status: REVIEWED

      Source sequence(s)
      AI843782, AK076037, AU067294
      Consensus CDS
      CCDS24931.1
      UniProtKB/Swiss-Prot
      P50544
      Related
      ENSMUSP00000099634, OTTMUSP00000006273, ENSMUST00000102574, OTTMUST00000013531
      Conserved Domains (2) summary
      cd01161
      Location:73482
      VLCAD; Very long chain acyl-CoA dehydrogenase
      COG1960
      Location:95474
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      70010183..70015428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187026.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      114670..119915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)