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    STE2 alpha-factor pheromone receptor STE2 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 850518, updated on 16-Jul-2015
    Gene symbol
    STE2
    Gene description
    alpha-factor pheromone receptor STE2
    Primary source
    SGD:S000001868
    Locus tag
    YFL026W
    Gene type
    protein coding
    RNA name
    alpha-factor pheromone receptor STE2
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See STE2 in MapViewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (82580..83875)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene putative ATP-binding cassette family ATPase CAF16 Neighboring gene Gyp8p Neighboring gene Bst1p Neighboring gene Epl1p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe MAPK/ERK pathway is a signal transduction pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. In many cell types, activation of this pathway p...
    • MAPK signaling pathway - yeast, organism-specific biosystem (from KEGG)
      MAPK signaling pathway - yeast, organism-specific biosystemThe S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third...
    • MAPK signaling pathway - yeast, conserved biosystem (from KEGG)
      MAPK signaling pathway - yeast, conserved biosystemThe S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third...
    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    mating-type alpha-factor pheromone receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mating-type alpha-factor pheromone receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mating-type alpha-factor pheromone receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mating-type alpha-factor pheromone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    mating-type factor pheromone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytogamy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytogamy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homooligomerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    response to pheromone IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISM
    Inferred from Sequence Model
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    alpha-factor pheromone receptor STE2
    NP_116627.2
    • Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      82580..83875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179940.2NP_116627.2  alpha-factor pheromone receptor STE2 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_116627.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTK4
      Conserved Domains (1) summary
      pfam02116
      Location:17297
      STE2; Fungal pheromone mating factor STE2 GPCR