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    Aplp2 amyloid beta (A4) precursor-like protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 11804, updated on 3-Jul-2016
    Official Symbol
    Aplp2provided by MGI
    Official Full Name
    amyloid beta (A4) precursor-like protein 2provided by MGI
    Primary source
    MGI:MGI:88047
    See related
    Ensembl:ENSMUSG00000031996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APLP-2; AI790698
    Orthologs
    Location:
    9 16.66 cM; 9 A2-B
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (31149557..31211862, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (30957142..31019400, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105244993 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene suppression of tumorigenicity 14 (colon carcinoma) Neighboring gene protein CEBPZOS pseudogene Neighboring gene predicted gene, 33535 Neighboring gene predicted gene 7244 Neighboring gene PR domain containing 10 Neighboring gene predicted gene 10910

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryo development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    midbrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of epidermal growth factor-activated receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    suckling behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    amyloid-like protein 2
    Names
    CDE1-binding protein CDEBP
    CDEBP
    CDEI box-binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102455.1NP_001095925.1  amyloid-like protein 2 isoform a precursor

      See identical proteins and their annotated locations for NP_001095925.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK150020, AK164012, BC051999, Z22592
      Consensus CDS
      CCDS52749.1
      UniProtKB/Swiss-Prot
      Q06335
      UniProtKB/TrEMBL
      Q3TPZ7, Q3UDL6, Q60709
      Related
      ENSMUSP00000072428, ENSMUST00000072634
      Conserved Domains (6) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam12924
      Location:149204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      cd00109
      Location:308361
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02177
      Location:48147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:696747
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:365548
      APP_E2; E2 domain of amyloid precursor protein
    2. NM_001102456.1NP_001095926.1  amyloid-like protein 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001095926.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and contains another alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK150020, BC051999, Z22592
      Consensus CDS
      CCDS52748.1
      UniProtKB/Swiss-Prot
      Q06335
      UniProtKB/TrEMBL
      Q3UDL6
      Related
      ENSMUSP00000078694, ENSMUST00000079758
      Conserved Domains (5) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam12924
      Location:149204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam02177
      Location:48147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:652703
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:309492
      APP_E2; E2 domain of amyloid precursor protein
    3. NM_009691.2NP_033821.1  amyloid-like protein 2 isoform c precursor

      See identical proteins and their annotated locations for NP_033821.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC114542, CT025678
      UniProtKB/TrEMBL
      Q64348
      Conserved Domains (5) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam12924
      Location:149204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam02177
      Location:48147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:640691
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:309492
      APP_E2; E2 domain of amyloid precursor protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      31149557..31211862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509951.3XP_006510014.1  

      See identical proteins and their annotated locations for XP_006510014.1

      UniProtKB/TrEMBL
      Q61482
      Conserved Domains (6) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam12924
      Location:149204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      cd00109
      Location:308361
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02177
      Location:48147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:708759
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:365548
      APP_E2; E2 domain of amyloid precursor protein
    2. XM_006509952.1XP_006510015.1  

      Conserved Domains (6) summary
      smart00006
      Location:1151
      A4_EXTRA; amyloid A4
      pfam12924
      Location:96151
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      cd00109
      Location:255308
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam02177
      Location:194
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:655706
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:312495
      APP_E2; E2 domain of amyloid precursor protein