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    HSPB2 heat shock protein family B (small) member 2 [ Homo sapiens (human) ]

    Gene ID: 3316, updated on 3-Jul-2016
    Official Symbol
    HSPB2provided by HGNC
    Official Full Name
    heat shock protein family B (small) member 2provided by HGNC
    Primary source
    HGNC:HGNC:5247
    See related
    Ensembl:ENSG00000170276 Ensembl:ENSG00000254445 HPRD:03712; MIM:602179; Vega:OTTHUMG00000166887
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MKBP; HSP27; Hs.78846; LOH11CR1K
    Summary
    The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]
    Orthologs
    Location:
    11q23.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (111912736..111914093)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111783460..111784817)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene chromosome 11 open reading frame 1 Neighboring gene ribosomal protein L37a pseudogene 8 Neighboring gene HSPB2-C11orf52 readthrough (NMD candidate) Neighboring gene uncharacterized LOC105369494 Neighboring gene crystallin alpha B Neighboring gene chromosome 11 open reading frame 52 Neighboring gene DIX domain containing 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Readthrough HSPB2-C11orf52

    Readthrough gene: HSPB2-C11orf52, Included gene: C11orf52

    Homology

    Clone Names

    • MGC133245

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to unfolded protein NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    heat shock protein beta-2
    Names
    DMPK-binding protein
    heat shock 27kDa protein 2
    heat-shock protein beta-2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033080.1 RefSeqGene

      Range
      5001..6358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001541.3NP_001532.1  heat shock protein beta-2

      See identical proteins and their annotated locations for NP_001532.1

      Status: REVIEWED

      Source sequence(s)
      AB096250, AI131288
      Consensus CDS
      CCDS8352.1
      UniProtKB/Swiss-Prot
      Q16082
      UniProtKB/TrEMBL
      A8KAH6
      Related
      ENSP00000302476, OTTHUMP00000234293, ENST00000304298, OTTHUMT00000391669
      Conserved Domains (1) summary
      cl00175
      Location:67148
      alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      111912736..111914093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      111666540..111667897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)