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CSNK2A1 casein kinase 2, alpha 1 polypeptide [ Homo sapiens (human) ]

Gene ID: 1457, updated on 11-Sep-2014
Official Symbol
CSNK2A1provided by HGNC
Official Full Name
casein kinase 2, alpha 1 polypeptideprovided by HGNC
Primary source
HGNC:HGNC:2457
See related
Ensembl:ENSG00000101266; HPRD:00277; MIM:115440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKII; CK2A1; CSNK2A3
Summary
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]
See CSNK2A1 in Epigenomics, MapViewer
Location:
20p13
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (473322..543838, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (463338..524482, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RanBP-type and C3HC4-type zinc finger containing 1 Neighboring gene TBC1 domain family, member 20 Neighboring gene transcription factor 15 (basic helix-loop-helix) Neighboring gene sulfiredoxin 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, casein kinase 2 alpha 1 polypeptide (CSNK2A1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CSNK2A1 is decreased by RRE PubMed
rev CK2 modulates the interaction of Rev with nucleolar phosphoprotein B23 by phosphorylating B23 PubMed
rev Rev activates CK2, an effect hypothesized to promote HIV-1 replication PubMed
rev phosphorylation of Rev is dependent on the beta subunit of CK2 PubMed
rev amino acids 35-50 of Rev are involved with electrostatic interactions with CK2 while amino acids 12-24 of Rev are involved with hydrophobic interactions PubMed
rev CK2 phosphorylates Rev on Serine 5 and Serine 8 PubMed
Vpu vpu Phosphorylation of HIV-1 Vpu by casein kinase 2 is required for Vpu-mediated degradation of CD4, regulation of HIV-1 envelope secretion and control of syncytium formation PubMed
vpu The HIV-1 Vpu protein is phosphorylated by casein kinase 2 on serine amino acids 52 and 56 PubMed
matrix gag CK2 has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
retropepsin gag-pol Purified recombinant HIV-1 protease (rPR) is phosphorylated by casein kinase II, and the activity of rPR is stimulated approximately 2.9-fold as a result of this phosphorylation PubMed
reverse transcriptase gag-pol Casein kinase II phosphorylates HIV-1 RT p66 and p51 in human cells PubMed
gag-pol Phosphorylation of HIV-1 RT p66 and p51 by Casein kinase II mediates the stimulation of RNA-dependent DNA polymerase (RDDP) activity in vitro PubMed

Go to the HIV-1, Human Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding TAS
Traceable Author Statement
more info
PubMed 
beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
chaperone-mediated protein folding TAS
Traceable Author Statement
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic spindle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth IDA
Inferred from Direct Assay
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with PcG protein complex IDA
Inferred from Direct Assay
more info
 
Sin3 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
casein kinase II subunit alpha
Names
casein kinase II subunit alpha
CK II alpha 3
protein kinase CK2
CK2 catalytic subunit alpha
casein kinase II alpha 1 subunit
casein kinase II alpha 1 polypeptide pseudogene
NP_001886.1
NP_808227.1
NP_808228.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011970.1 

    Range
    5001..66145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001895.3NP_001886.1  casein kinase II subunit alpha isoform a

    See proteins identical to NP_001886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF011920, AU133318, BC053532, M55265
    Consensus CDS
    CCDS13003.1
    UniProtKB/Swiss-Prot
    P68400
    Related
    ENSP00000479630, ENST00000619188
    Conserved Domains (3) summary
    pfam00069
    Location:39324
    Pkinase; Protein kinase domain
    pfam12484
    Location:332389
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal
    cl09925
    Location:39324
    PKc_like; Protein Kinases, catalytic domain
  2. NM_177559.2NP_808227.1  casein kinase II subunit alpha isoform a

    See proteins identical to NP_808227.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF011920, AU132198, BC053532, M55265
    Consensus CDS
    CCDS13003.1
    UniProtKB/Swiss-Prot
    P68400
    Conserved Domains (3) summary
    pfam00069
    Location:39324
    Pkinase; Protein kinase domain
    pfam12484
    Location:332389
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal
    cl09925
    Location:39324
    PKc_like; Protein Kinases, catalytic domain
  3. NM_177560.2NP_808228.1  casein kinase II subunit alpha isoform b

    See proteins identical to NP_808228.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR as well as the first coding exon compared to variant 1, resulting in an isoform (b) which is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AF011920, AU132198, AY735339, BC053532, M55265
    Consensus CDS
    CCDS13004.1
    UniProtKB/Swiss-Prot
    P68400
    Conserved Domains (2) summary
    pfam12484
    Location:196253
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal
    cl09925
    Location:1188
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    473322..543838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723548.1XP_006723611.1  

    See proteins identical to XP_006723611.1

    UniProtKB/Swiss-Prot
    P68400
    Conserved Domains (3) summary
    pfam00069
    Location:39324
    Pkinase; Protein kinase domain
    pfam12484
    Location:332389
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal
    cl09925
    Location:39324
    PKc_like; Protein Kinases, catalytic domain

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    414534..475783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    463361..524481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)