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    POSTN periostin, osteoblast specific factor [ Homo sapiens (human) ]

    Gene ID: 10631, updated on 24-Aug-2015
    Official Symbol
    POSTNprovided by HGNC
    Official Full Name
    periostin, osteoblast specific factorprovided by HGNC
    Primary source
    HGNC:HGNC:16953
    See related
    Ensembl:ENSG00000133110; HPRD:12295; MIM:608777; Vega:OTTHUMG00000016751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PN; OSF2; OSF-2; PDLPOSTN; periostin
    Orthologs
    See POSTN in Epigenomics, MapViewer
    Location:
    13q13.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (37562582..37598844, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (38136719..38172981, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1048 Neighboring gene long intergenic non-protein coding RNA 547 Neighboring gene transient receptor potential cation channel, subfamily C, member 4 Neighboring gene uncharacterized LOC101929077 Neighboring gene heat shock 60kDa protein 1 (chaperonin) pseudogene 9

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.
    NHGRI GWA Catalog
    Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced downregulation of periostin, osteoblast specific factor (POSTN) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Markers

    Homology

    Clone Names

    • MGC119510, MGC119511

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    proteinaceous extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    proteinaceous extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    periostin
    Names
    osteoblast specific factor 2 (fasciclin I-like)
    periodontal ligament-specific periostin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135934.1NP_001129406.1  periostin isoform 2 precursor

      See identical proteins and their annotated locations for NP_001129406.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI580215, BC106710, BG938993, DC403736
      Consensus CDS
      CCDS45034.1
      UniProtKB/TrEMBL
      A0A024RDT5
      UniProtKB/Swiss-Prot
      Q15063
      Related
      ENSP00000369066, OTTHUMP00000018269, ENST00000379742, OTTHUMT00000044567
      Conserved Domains (2) summary
      pfam02469
      Location:245367
      Fasciclin; Fasciclin domain
      pfam07546
      Location:4087
      EMI; EMI domain
    2. NM_001135935.1NP_001129407.1  periostin isoform 3 precursor

      See identical proteins and their annotated locations for NP_001129407.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (3, also known as thy6) is shorter than isoform 1.
      Source sequence(s)
      AI580215, AY140646, BQ575951, DC403736
      Consensus CDS
      CCDS53864.1
      UniProtKB/Swiss-Prot
      Q15063
      Related
      ENSP00000437959, ENST00000541179
      Conserved Domains (2) summary
      pfam02469
      Location:245367
      Fasciclin; Fasciclin domain
      pfam07546
      Location:4087
      EMI; EMI domain
    3. NM_001135936.1NP_001129408.1  periostin isoform 4 precursor

      See identical proteins and their annotated locations for NP_001129408.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AI580215, AY918092, BP335818, BQ575951, BY795054, DC403736
      UniProtKB/Swiss-Prot
      Q15063
      Conserved Domains (2) summary
      pfam02469
      Location:245367
      Fasciclin; Fasciclin domain
      pfam07546
      Location:4087
      EMI; EMI domain
    4. NM_001286665.1NP_001273594.1  periostin isoform 5 precursor

      See identical proteins and their annotated locations for NP_001273594.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (5, also known as thy2) is shorter than isoform 1.
      Source sequence(s)
      AI580215, AY140646, BQ575951, DC403736, EU262883
      Consensus CDS
      CCDS66531.1
      UniProtKB/Swiss-Prot
      Q15063
      Related
      ENSP00000369067, OTTHUMP00000018270, ENST00000379743, OTTHUMT00000044568
      Conserved Domains (2) summary
      pfam02469
      Location:245367
      Fasciclin; Fasciclin domain
      pfam07546
      Location:4087
      EMI; EMI domain
    5. NM_001286666.1NP_001273595.1  periostin isoform 6 precursor

      See identical proteins and their annotated locations for NP_001273595.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (6, also known as thy4) is shorter than isoform 1.
      Source sequence(s)
      AI580215, AY140646, BQ575951, DC403736, EU262884
      Consensus CDS
      CCDS66530.1
      UniProtKB/Swiss-Prot
      Q15063
      Related
      ENSP00000437953, ENST00000541481
      Conserved Domains (2) summary
      pfam02469
      Location:245367
      Fasciclin; Fasciclin domain
      pfam07546
      Location:4087
      EMI; EMI domain
    6. NM_001286667.1NP_001273596.1  periostin isoform 7 precursor

      See identical proteins and their annotated locations for NP_001273596.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks four alternate in-frame exons, compared to variant 1. The encoded isoform (7, also known as thy8) is shorter than isoform 1.
      Source sequence(s)
      AI580215, AY140646, BQ575951, DC403736, EU262886
      UniProtKB/Swiss-Prot
      Q15063
      Conserved Domains (2) summary
      pfam02469
      Location:245367
      Fasciclin; Fasciclin domain
      pfam07546
      Location:4087
      EMI; EMI domain
    7. NM_006475.2NP_006466.2  periostin isoform 1 precursor

      See identical proteins and their annotated locations for NP_006466.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI580215, BC106709, BQ575951, D13666, DC403736
      Consensus CDS
      CCDS9364.1
      UniProtKB/TrEMBL
      A0A024RDS2
      UniProtKB/Swiss-Prot
      Q15063
      Related
      ENSP00000369071, OTTHUMP00000018268, ENST00000379747, OTTHUMT00000044566
      Conserved Domains (2) summary
      pfam02469
      Location:245367
      Fasciclin; Fasciclin domain
      pfam07546
      Location:4087
      EMI; EMI domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

      Range
      37562582..37598844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266232.2XP_005266289.1  

      Conserved Domains (2) summary
      pfam02469
      Location:245367
      Fasciclin; Fasciclin domain
      pfam07546
      Location:4087
      EMI; EMI domain
    2. XM_005266231.2XP_005266288.1  

      See identical proteins and their annotated locations for XP_005266288.1

      UniProtKB/TrEMBL
      B1ALD9
      Related
      ENSP00000369073, OTTHUMP00000018271, ENST00000379749, OTTHUMT00000044569
      Conserved Domains (2) summary
      pfam02469
      Location:245367
      Fasciclin; Fasciclin domain
      pfam07546
      Location:4087
      EMI; EMI domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      38104259..38140559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)