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SYMPK symplekin [ Homo sapiens (human) ]

Gene ID: 8189, updated on 6-Jul-2014
Official Symbol
SYMPKprovided by HGNC
Official Full Name
symplekinprovided by HGNC
Primary source
HGNC:22935
Locus tag
hCG_20812
See related
Ensembl:ENSG00000125755; HPRD:09090; MIM:602388; Vega:OTTHUMG00000150151
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPK; SYM
Summary
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
See SYMPK in Epigenomics, MapViewer
Location:
19q13.3
Exon count :
27
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (45815442..45863290, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46318700..46366548, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene dystrophia myotonica, WD repeat containing Neighboring gene radial spoke head 6 homolog A (Chlamydomonas) Neighboring gene forkhead box A3 Neighboring gene interferon regulatory factor 2 binding protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
mRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
tight junction IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004819.2NP_004810.2  symplekin

    See proteins identical to NP_004810.2

    Status: REVIEWED

    Source sequence(s)
    BC006536, BU752018, DB044963, DB461873, Y10931
    Consensus CDS
    CCDS12676.2
    UniProtKB/Swiss-Prot
    Q92797
    Related
    ENSP00000245934, OTTHUMP00000196465, ENST00000245934, OTTHUMT00000316581
    Conserved Domains (2) summary
    pfam11935
    Location:117352
    Blast Score: 754
    DUF3453; Domain of unknown function (DUF3453)
    pfam12295
    Location:8871069
    Blast Score: 670
    Symplekin_C; Symplekin tight junction protein C terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    45815442..45863290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259286.1XP_005259343.1  

    See proteins identical to XP_005259343.1

    UniProtKB/Swiss-Prot
    Q92797
    Conserved Domains (2) summary
    pfam11935
    Location:117352
    Blast Score: 754
    DUF3453; Domain of unknown function (DUF3453)
    pfam12295
    Location:8871069
    Blast Score: 670
    Symplekin_C; Symplekin tight junction protein C terminal

RNA

  1. XR_243962.2 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    42747182..42795062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    46321187..46369025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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