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CASP8AP2 caspase 8 associated protein 2 [ Homo sapiens (human) ]

Gene ID: 9994, updated on 27-Apr-2015
Official Symbol
CASP8AP2provided by HGNC
Official Full Name
caspase 8 associated protein 2provided by HGNC
Primary source
HGNC:HGNC:1510
See related
Ensembl:ENSG00000118412; HPRD:06048; MIM:606880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CED-4; FLASH; RIP25
Summary
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]
Annotation information
Annotation category: partial on reference assembly
Orthologs
See CASP8AP2 in MapViewer
Location:
6q15
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (89829900..89874436)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (90539619..90584155)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene MDN1, midasin homolog (yeast) Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 19 pseudogene 6 Neighboring gene family with sequence similarity 64, member A pseudogene Neighboring gene ribosomal protein L22 pseudogene 14 Neighboring gene G protein pathway suppressor 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of caspase 8 associated protein 2 (CASP8AP2) in human B cells PubMed
Vpr vpr Overexpression of CASP8AP2 is induced by HIV-1 Vpr in the transfected 293T cells PubMed

Go to the HIV-1, Human Interaction Database

  • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11208, KIAA1315

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
SUMO polymer binding IDA
Inferred from Direct Assay
more info
PubMed 
cysteine-type endopeptidase activator activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
death receptor binding TAS
Traceable Author Statement
more info
PubMed 
peptidase activator activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
CASP8-associated protein 2
Names
CASP8-associated protein 2
CASP8 associated protein 2
CASP8AP2
FLASH homolog RIP25
FLICE associated huge
FLICE-associated huge protein
human FLASH

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137667.1NP_001131139.1  CASP8-associated protein 2

    See identical proteins and their annotated locations for NP_001131139.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AF154415, BC132828, BP363682
    UniProtKB/Swiss-Prot
    Q9UKL3
    Conserved Domains (1) summary
    cd12202
    Location:19161980
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
  2. NM_001137668.1NP_001131140.1  CASP8-associated protein 2

    See identical proteins and their annotated locations for NP_001131140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AF154415, BC132828, BP192859
    UniProtKB/Swiss-Prot
    Q9UKL3
    Conserved Domains (1) summary
    cd12202
    Location:19161980
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
  3. NM_012115.3NP_036247.1  CASP8-associated protein 2

    See identical proteins and their annotated locations for NP_036247.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AF154415, BC132830, BP363682
    UniProtKB/Swiss-Prot
    Q9UKL3
    Related
    ENSP00000478179, ENST00000551025
    Conserved Domains (1) summary
    cd12202
    Location:19161980
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    89829900..89874436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    90637186..90681833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)