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Nbn nibrin [ Mus musculus (house mouse) ]

Gene ID: 27354, updated on 5-Apr-2015
Official Symbol
Nbnprovided by MGI
Official Full Name
nibrinprovided by MGI
Primary source
MGI:MGI:1351625
See related
Ensembl:ENSMUSG00000028224; Vega:OTTMUSG00000004636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nbs1
Orthologs
See Nbn in MapViewer
Location:
4; 4 A
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (15957967..15992589)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (15885114..15919736)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene calbindin 1 Neighboring gene 2,4-dienoyl CoA reductase 1, mitochondrial Neighboring gene microRNA 6400 Neighboring gene predicted gene 11869 Neighboring gene oxidative stress induced growth inhibitor family member 2 Neighboring gene predicted gene 11870 Neighboring gene receptor (TNFRSF)-interacting serine-threonine kinase 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ATP-dependent DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
PubMed 
DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
blastocyst growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
isotype switching IDA
Inferred from Direct Assay
more info
PubMed 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mitotic G2 DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic G2 DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
mitotic cell cycle checkpoint ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Mre11 complex ISO
Inferred from Sequence Orthology
more info
 
PML body ISO
Inferred from Sequence Orthology
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nuclear inclusion body ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
replication fork IDA
Inferred from Direct Assay
more info
PubMed 
site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
nibrin
Names
nibrin
cell cycle regulatory protein p95
nijmegen breakage syndrome protein 1 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013752.3NP_038780.3  nibrin

    See identical proteins and their annotated locations for NP_038780.3

    Status: VALIDATED

    Source sequence(s)
    BC013190, BC055061
    Consensus CDS
    CCDS17986.1
    UniProtKB/Swiss-Prot
    Q9R207
    Related
    ENSMUSP00000029879, OTTMUSP00000004959, ENSMUST00000029879, OTTMUST00000010463
    Conserved Domains (3) summary
    pfam08599
    Location:680744
    Nbs1_C; DNA damage repair protein Nbs1
    cd00027
    Location:114182
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00060
    Location:1109
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    15957967..15992589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537970.1XP_006538033.1  

    See identical proteins and their annotated locations for XP_006538033.1

    Conserved Domains (1) summary
    pfam08599
    Location:529593
    Nbs1_C; DNA damage repair protein Nbs1
  2. XM_006537971.1XP_006538034.1  

    See identical proteins and their annotated locations for XP_006538034.1

    Conserved Domains (1) summary
    pfam08599
    Location:529593
    Nbs1_C; DNA damage repair protein Nbs1

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    15761229..15795887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)