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    Raf1 v-raf-leukemia viral oncogene 1 [ Mus musculus (house mouse) ]

    Gene ID: 110157, updated on 26-Jun-2016
    Official Symbol
    Raf1provided by MGI
    Official Full Name
    v-raf-leukemia viral oncogene 1provided by MGI
    Primary source
    MGI:MGI:97847
    See related
    Ensembl:ENSMUSG00000000441 Vega:OTTMUSG00000020697
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Craf1; Raf-1; c-Raf; v-Raf; AA990557; BB129353; 6430402F14Rik; D830050J10Rik
    Orthologs
    Location:
    6 C3; 6 53.62 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (115618573..115676635, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (115568591..115626653, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene makorin, ring finger protein 2, opposite strand Neighboring gene makorin, ring finger protein, 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene RIKEN cDNA D830050J10 gene Neighboring gene predicted gene, 38879 Neighboring gene transmembrane protein 40

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC102375

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Ras GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor signaling protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    death-inducing signaling complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    face development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intermediate filament cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    neurotrophin TRK receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to muscle stretch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    somatic stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    thymus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    pseudopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    RAF proto-oncogene serine/threonine-protein kinase
    Names
    Craf1 transforming
    cRaf
    murine sarcoma 3611 oncogene 1
    proto-oncogene c-RAF
    sarcoma 3611 oncogene
    v-raf-1 leukemia viral oncogene 1
    NP_084056.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029780.3NP_084056.1  RAF proto-oncogene serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_084056.1

      Status: PROVISIONAL

      Source sequence(s)
      AK141745
      Consensus CDS
      CCDS20441.1
      UniProtKB/Swiss-Prot
      Q99N57
      Related
      ENSMUSP00000000451, OTTMUSP00000022608, ENSMUST00000000451, OTTMUST00000048983
      Conserved Domains (4) summary
      cd01816
      Location:57131
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd00029
      Location:139184
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00069
      Location:354605
      Pkinase; Protein kinase domain
      cd14149
      Location:336618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      115618573..115676635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505363.3XP_006505426.1  

      See identical proteins and their annotated locations for XP_006505426.1

      UniProtKB/Swiss-Prot
      Q99N57
      Conserved Domains (4) summary
      cd01816
      Location:57131
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd00029
      Location:139184
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00069
      Location:374625
      Pkinase; Protein kinase domain
      cd14149
      Location:356638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    2. XM_006505365.2XP_006505428.1  

      See identical proteins and their annotated locations for XP_006505428.1

      UniProtKB/Swiss-Prot
      Q99N57
      Related
      ENSMUSP00000108571, OTTMUSP00000022609, ENSMUST00000112949, OTTMUST00000048985
      Conserved Domains (4) summary
      cd01816
      Location:57131
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd00029
      Location:139184
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00069
      Location:354605
      Pkinase; Protein kinase domain
      cd14149
      Location:336618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    3. XM_006505364.2XP_006505427.1  

      See identical proteins and their annotated locations for XP_006505427.1

      UniProtKB/Swiss-Prot
      Q99N57
      Conserved Domains (4) summary
      cd01816
      Location:57131
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd00029
      Location:139184
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00069
      Location:374625
      Pkinase; Protein kinase domain
      cd14149
      Location:356638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase