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Cbfb core binding factor beta [ Mus musculus (house mouse) ]

Gene ID: 12400, updated on 18-Mar-2015
Official Symbol
Cbfbprovided by MGI
Official Full Name
core binding factor betaprovided by MGI
Primary source
MGI:MGI:99851
See related
Ensembl:ENSMUSG00000031885; Vega:OTTMUSG00000049550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PEA2; Pebp2; PEBP2b; Pebpb2; AI893578
Orthologs
See Cbfb in MapViewer
Location:
8 D3; 8 53.04 cM
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (105170674..105217989)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (107694574..107741889)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein, RP/EB family, member 1 pseudogene Neighboring gene carboxylesterase 4A Neighboring gene RIKEN cDNA D230025D16 gene Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene TNFRSF1A-associated via death domain

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
core-binding factor subunit beta
Names
core-binding factor subunit beta
CBF-beta
PEA2-beta
PEBP2-beta
SL3-3 enhancer factor 1 subunit beta
SL3/AKV core-binding factor beta subunit
polyomavirus enhancer-binding protein 2 beta subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161456.1NP_001154928.1  core-binding factor subunit beta isoform 2

    See proteins identical to NP_001154928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC164311, BF661733, D14572
    Consensus CDS
    CCDS52656.1
    UniProtKB/Swiss-Prot
    Q08024
    Related
    ENSMUSP00000105021, OTTMUSP00000068325, ENSMUST00000109394, OTTMUST00000126297
    Conserved Domains (1) summary
    pfam02312
    Location:1132
    CBF_beta; Core binding factor beta subunit
  2. NM_001161457.1NP_001154929.1  core-binding factor subunit beta isoform 3

    See proteins identical to NP_001154929.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC164311, BF661733, D14570
    Consensus CDS
    CCDS52655.1
    UniProtKB/Swiss-Prot
    Q08024
    Related
    ENSMUSP00000105022, OTTMUSP00000068324, ENSMUST00000109395, OTTMUST00000126296
    Conserved Domains (1) summary
    pfam02312
    Location:1133
    CBF_beta; Core binding factor beta subunit
  3. NM_001161458.1NP_001154930.1  core-binding factor subunit beta isoform 4

    See proteins identical to NP_001154930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3# coding region which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC164311, BF661733, D14571
    Consensus CDS
    CCDS52654.1
    UniProtKB/Swiss-Prot
    Q08024
    Related
    ENSMUSP00000105019, OTTMUSP00000068323, ENSMUST00000109392, OTTMUST00000126295
    Conserved Domains (1) summary
    pfam02312
    Location:1170
    CBF_beta; Core binding factor beta subunit
  4. NM_022309.4NP_071704.3  core-binding factor subunit beta isoform 1

    See proteins identical to NP_071704.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC164311, BF661733, D14572
    Consensus CDS
    CCDS22592.1
    UniProtKB/Swiss-Prot
    Q08024
    Related
    ENSMUSP00000059382, OTTMUSP00000068322, ENSMUST00000052209, OTTMUST00000126293
    Conserved Domains (1) summary
    pfam02312
    Location:1171
    CBF_beta; Core binding factor beta subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    105170674..105217989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    109393261..109440736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)