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    Lep leptin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25608, updated on 23-Aug-2015
    Official Symbol
    Lepprovided by RGD
    Official Full Name
    leptinprovided by RGD
    Primary source
    RGD:3000
    See related
    Ensembl:ENSRNOG00000045797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    OB; obese
    Summary
    involved in regulation of body weight, and may have a role in angiogenesis [RGD, Feb 2006]
    Orthologs
    See Lep in MapViewer
    Location:
    4q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56337695..56351818)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (56085079..56099209)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene staphylococcal nuclease and tudor domain containing 1 Neighboring gene leucine rich repeat containing 4 Neighboring gene microRNA 129-1 Neighboring gene RNA binding motif protein 28 Neighboring gene proline-rich transmembrane protein 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cytokine activity TAS
    Traceable Author Statement
    more info
    PubMed 
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    JAK-STAT cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    adipose tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    adipose tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    adult feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    adult feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    bile acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    bone mineralization involved in bone maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cAMP-mediated signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    cardiac muscle hypertrophy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to L-ascorbic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    central nervous system neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    energy reserve metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glycerol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    leptin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte tethering or rolling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of appetite ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of appetite ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of cartilage development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell size IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of glucagon secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glucagon secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glutamine transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vasoconstriction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ovulation from ovarian follicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JAK-STAT cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of STAT protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of STAT protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytokine production IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of developmental growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of follicle-stimulating hormone secretion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of hepatic stellate cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of luteinizing hormone secretion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of myeloid cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peroxisome proliferator activated receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of Stat3 protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of intestinal cholesterol absorption IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of intestinal cholesterol absorption ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lipoprotein lipid oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to dietary excess IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
     
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to vitamin E IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
     
    tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    leptin
    Names
    obesity factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013076.3NP_037208.1  leptin precursor

      See identical proteins and their annotated locations for NP_037208.1

      Status: VALIDATED

      Source sequence(s)
      AC096035
      UniProtKB/Swiss-Prot
      P50596
      Related
      ENSRNOP00000066184, ENSRNOT00000071926
      Conserved Domains (1) summary
      pfam02024
      Location:22167
      Leptin; Leptin

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      56337695..56351818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762762.1XP_008760984.1  

      See identical proteins and their annotated locations for XP_008760984.1

      UniProtKB/Swiss-Prot
      P50596
      Conserved Domains (1) summary
      pfam02024
      Location:22167
      Leptin; Leptin

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      52770132..52784148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)