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    Tbxa2r thromboxane A2 receptor [ Mus musculus (house mouse) ]

    Gene ID: 21390, updated on 4-Jul-2015
    Official Symbol
    Tbxa2rprovided by MGI
    Official Full Name
    thromboxane A2 receptorprovided by MGI
    Primary source
    MGI:MGI:98496
    See related
    Ensembl:ENSMUSG00000034881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TP; TXA2-R
    Summary
    This gene encodes a multi-pass membrane protein that functions as a G-protein coupled receptor. The encoded protein binds thromboxane A2, resulting in the aggregation of platelets and constriction of blood vessels. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Mar 2013]
    Orthologs
    See Tbxa2r in Epigenomics, MapViewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (81328259..81335184)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80791476..80797917)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma Neighboring gene cactin, spliceosome C complex subunit Neighboring gene GIPC PDZ domain containing family, member 3 Neighboring gene high mobility group 20B

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC107665

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    thromboxane receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thromboxane receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of vasoconstriction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    second-messenger-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    thromboxane A2 receptor
    Names
    TXA2 receptor
    prostanoid TP receptor
    thromboxane prostanoid

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277265.1NP_001264194.1  thromboxane A2 receptor

      See identical proteins and their annotated locations for NP_001264194.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC155937, AI841195, AK158477
      Consensus CDS
      CCDS24053.1
      UniProtKB/Swiss-Prot
      P30987
      UniProtKB/TrEMBL
      Q5FW61
      Related
      ENSMUSP00000100962, ENSMUST00000105325
      Conserved Domains (1) summary
      pfam00001
      Location:59305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_009325.4NP_033351.1  thromboxane A2 receptor

      See identical proteins and their annotated locations for NP_033351.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC155937, AI841195, AK158477, BC138885
      Consensus CDS
      CCDS24053.1
      UniProtKB/Swiss-Prot
      P30987
      UniProtKB/TrEMBL
      Q5FW61
      Conserved Domains (1) summary
      pfam00001
      Location:59305
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

      Range
      81328259..81335184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513460.2XP_006513523.1  

      See identical proteins and their annotated locations for XP_006513523.1

      UniProtKB/Swiss-Prot
      P30987
      UniProtKB/TrEMBL
      Q5FW61
      Conserved Domains (1) summary
      pfam00001
      Location:59305
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate Mm_Celera

    Genomic

    1. AC_000032.1 Alternate Mm_Celera

      Range
      82349438..82355972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)