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    CD209 CD209 molecule [ Homo sapiens (human) ]

    Gene ID: 30835, updated on 26-Jul-2015
    Official Symbol
    CD209provided by HGNC
    Official Full Name
    CD209 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1641
    See related
    Ensembl:ENSG00000090659; HPRD:05241; MIM:604672; Vega:OTTHUMG00000182530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1
    Summary
    This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
    Orthologs
    See CD209 in Epigenomics, MapViewer
    Location:
    19p13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (7739988..7747605, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7804879..7812499, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372262 Neighboring gene C-type lectin domain family 4, member G Neighboring gene zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 pseudogene Neighboring gene ribosomal protein L21 pseudogene 129 Neighboring gene C-type lectin domain family 4, member M

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of DC-SIGN (CD209) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env A dendritic cells (DC)-specific C-type lectin, DC-SIGN, is highly expressed on DC present in mucosal tissues, binds to the HIV-1 envelope glycoprotein gp120, and facilitates infection of HIV-1 permissive cells in trans PubMed
    env The N-terminal DC-SIGN CRD region (residues 253-288) is essential for HIV-1 binding and transmission and Y258 is required for these activities, suggesting the N-terminal CRD region involves the interaction of DC-SIGN with gp120 PubMed
    env Natural antibodies against the carbohydrate recognition domain (CRD) of DC-SIGN block the attachment of HIV-1 to DC-SIGN-positive cells and inhibit transmission in trans of HIV-1 to T cells, suggesting the CRD is important for its interaction with gp120 PubMed
    env Binding of HIV-1 gp120 to DC-SIGN leads to excessive ASK-1 activation and promotes ASK-1-dependent apoptosis in human dendritic cells PubMed
    env Binding of HIV-1 gp120 to DC-SIGN sensitizes monocyte-derived dendritic cells for CD40L-mediated apoptosis PubMed
    env HIV-1 gp120 downregulates HIV-1 Nef dependent IL-6 release, which requires the interaction of gp120 with DC-SIGN in immature dentritic cells PubMed
    env CD4-linker-DC-SIGN fusion proteins enhance binding affinity to HIV-1 gp140 and gp120 in comparison to sCD4 and sDC-SIGN. These fusion proteins inhibit HIV-1 capture and transfer via DC-SIGN-expressing cells and iMDDCs PubMed
    env DC-SIGN is strongly upregulated in M2a-polarized monocyte-derived-macrophages (MDMs), which leads to facilitate HIV-1 entry via gp120/gp41 and DNA synthesis in M2a-MDMs and to efficiently transmit both R5 and X4 HIV-1 to CD4+ T cells PubMed
    env Enrichment of oligomannose N-glycans on HIV-1 gp120 enhances DC-SIGN binding but reduces the subsequent transmission to target cells PubMed
    env DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface subsequently activates Cdc42, Pak1, and Wasp, leading to an increase in membrane extensions at the DC surface PubMed
    env AM3 (Inmunoferon) inhibits the interaction of DC-SIGN with both ICAM3 and HIV-1 gp120 protein and blocks the DC-SIGN-dependent capture of HIV virions and the HIV trans-infection capability of DC-SIGN transfectants PubMed
    env Raji-DC-SIGN cells preferentially enhance CXCR4 usage of dual-tropic HIV-1 with higher V3 charges in gp120 PubMed
    env DC-SIGN triacidic cluster (353EEE355) mutant is impaired in receptor-mediated endocytosis of HIV-1 gp120 in transfected human myeloid K-562 cells PubMed
    env One HIV-1 gp120 triple glycosylation mutant form 134mut (carrying N293Q, N382Q, and N388Q mutations in gp120) exhibits a significant increase in sensitivity to both mannan competition and endoglycosidase H digestion in a DC-SIGN binding assay PubMed
    env Mermaid shares glycan specificity with DC-SIGN and inhibits the interaction between DC-SIGN and HIV-1 gp120 PubMed
    env Oligomannose glycans play as ligands for DC-SIGN, and can inhibit the binding of gp120 to 2G12 and recombinant dimeric DC-SIGN PubMed
    env End-stage CCR5-tropic HIV-1 have a reduced ability to use DC-SIGN resulting from the loss of potential N-linked glycosylation sites (PNGS) in the gp120 V2 and V4 regions, which are present in the majority of chronic stage CCR5-tropic variants PubMed
    env Expression of CD4 on Raji B cells strongly inhibits DC-SIGN-mediated HIV-1 (gp120) transmission to T cells; co-expression of CD4 and DC-SIGN in Raji cells promotes internalization and intracellular retention of HIV-1 PubMed
    env Monoclonal antibodies produced from hybridoma clones recognize DC-SIGN on monocyte-derived dendritic cells and on dermal-type macrophages to interfere with DC-SIGN binding to HIV-1 gp120 PubMed
    env Glycopolymers effectively prevent the interactions between a human dendritic cell associated lectin (DC-SIGN) and the HIV-1 gp120 PubMed
    env HIV-1 gp120 N275Q or N351Q mutants isolated from recombinant CRF07_BC decrease significantly to the DC-SIGN-binding capacity, indicating that the N275 and N351 glycan sites mediate the interaction between CRF07_BC gp120 and DC-SIGN PubMed
    env Using an siRNA approach indicates DC-SIGN is not required for efficient trans-enhancement of HIV-1 (gp120) infectivity by dendritic cells (DCs) PubMed
    env Bile salt-stimulated lipase (BSSL) isolated from human milk binds to DC-SIGN, preventing HIV-1 gp120 from interacting with this receptor PubMed
    env HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin PubMed
    env Interaction of gp120 with DC-SIGN activates Raf-1 and phosphorylates Raf-1 at positions Ser338, Tyr340, and Tyr341 PubMed
    env DC-SIGN-mediated blockage of HIV budding is due to internalization of gp120 by DC-SIGN. The 364 amino-acid residues of extracellular and transmembrane domains in DC-SIGN are essential for the blockage PubMed
    env Human milk oligosaccharides reduce HIV-1-gp120 binding to dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN) PubMed
    env Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR in combination with binding studies reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides of HIV-1 gp120 PubMed
    env The cis expression of DC-SIGN on multiple lymphoid cell lines enables more efficient entry and replication of CXCR4-tropic and CCR5/CXCR4 dual-tropic HIV-1 through its binding to the HIV-1 gp120-CD4-CXCR4 complex PubMed
    env Bovine lactoferrin (bLF) binds strongly to DC-SIGN, thus blocking the interaction between DC-SIGN and HIV-1 gp120 and preventing virus capture and subsequent transmission; bLF is a much more efficient inhibitor of transmission than human lactoferrin PubMed
    env Binding of HIV-1 gp120 to DC-SIGN does not result in increased adhesion levels of LFA-1 to its ligand ICAM-1 in both immature dendritic cells (DC) and Raji-DC-SIGN cells PubMed
    env DC-SIGN tetramers are essential for high affinity interactions with the HIV-1 high mannose glycoprotein gp120 PubMed
    env Mutagenesis of conserved residues (Gly-346, Glu-347, Asn-349, Glu-354, and Asp-355) of DC-SIGN significantly compromises binding to HIV-1 gp120 PubMed
    env DC-SIGN and MBL bind primarily to glycans on HIV-1 gp120/gp41; preincubation of CXCR4-, CCR5- or dual-tropic HIV-1 strains with MBL prevents DC-SIGN-mediated trans infection of T cells PubMed
    env The HIV-1 gp120 binding site in DC-SIGN is different from that of ICAM-2 and ICAM-3; alanine-scanning mutagenesis of DC-SIGN at N311, R345, V351, G352, E353, S360, G361, and N362 abrogate ICAM-2/3 binding, whereas the HIV-1 gp120 interaction is unaffected PubMed
    Envelope surface glycoprotein gp160, precursor env CD4-linker-DC-SIGN fusion proteins enhance binding affinity to HIV-1 gp140 and gp120 in comparison to sCD4 and sDC-SIGN. These fusion proteins inhibit HIV-1 capture and transfer via DC-SIGN-expressing cells and iMDDCs PubMed
    env Enrichment of oligomannose N-glycans on HIV-1 gp140 enhances DC-SIGN binding but reduces the subsequent transmission to target cells PubMed
    env DC-SIGN binding to the HIV envelope protein effectively increases exposure of the CD4 binding site, which leads to enhance the relative rate of infection of the CD4-dependent strain PubMed
    env DC-SIGN increases the binding affinity of trimeric gp140 envelope glycoproteins to CD4 on permissive cell surface PubMed
    Nef nef HIV-1 gp120 downregulates HIV-1 Nef dependent IL-6 release, which requires the interaction of gp120 with DC-SIGN in immature dentritic cells PubMed
    nef Mutation of the dileucine motif at amino acids 165-166 of HIV-1 Nef abolishes the Nef-mediated upregulation of DC-SIGN on the surface of HIV-1 infected dendritic cells PubMed
    nef HIV-1 Nef upregulates DC-SIGN in HIV-1 infected dendritic cells by inhibiting DC-SIGN endocytosis, which dramatically increases clustering of dendritic cells with T lymphocytes, thereby enhancing HIV-1 transmission PubMed
    nef Substitution of HIV-1 Nef acidic residue E160 with uncharged residues impairs the ability of Nef to upregulate the expression of DC-SIGN and the invariant chain of MHC class II at the cell surface PubMed

    Go to the HIV-1, Human Interaction Database

    • C-type lectin receptors (CLRs), organism-specific biosystem (from REACTOME)
      C-type lectin receptors (CLRs), organism-specific biosystemPathogen recognition is central to the induction of T cell differentiation. Groups of pathogens share similar structures known as pathogen-associated molecular patterns (PAMPs), which are recognised ...
    • CD209 (DC-SIGN) signaling, organism-specific biosystem (from REACTOME)
      CD209 (DC-SIGN) signaling, organism-specific biosystemCD209 (also called as DC-SIGN (DC-specific intracellular adhesion molecule-3-grabbing non-integrin)) is a type II transmembrane C-type lectin receptor preferentially expressed on dendritic cells (DCs...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC129965

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mannose binding TAS
    Traceable Author Statement
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptide antigen binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    virion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    antigen processing and presentation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell-cell recognition TAS
    Traceable Author Statement
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
     
    intracellular signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    intracellular transport of virus TAS
    Traceable Author Statement
    more info
    PubMed 
    leukocyte cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    modulation by virus of host morphology or physiology TAS
    Traceable Author Statement
    more info
    PubMed 
    peptide antigen transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    viral genome replication NAS
    Non-traceable Author Statement
    more info
    PubMed 
    virion attachment to host cell TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    CD209 antigen
    Names
    C-type lectin domain family 4 member L
    C-type lectin domain family 4, member L
    HIV gpl20-binding protein
    dendritic cell-specific ICAM-3-grabbing non-integrin 1
    dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012167.1 RefSeqGene

      Range
      5001..12586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144893.1NP_001138365.1  CD209 antigen isoform 5

      See identical proteins and their annotated locations for NP_001138365.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 5, which is shorter than isoform 1. The encoded isoform (5) lacks the transmembrane domain and has 4.5 repeats in the neck domain.
      Source sequence(s)
      AC008763, AK313585, AY042227
      Consensus CDS
      CCDS59344.1
      UniProtKB/TrEMBL
      B2R907
      UniProtKB/TrEMBL
      M0R0P0
      UniProtKB/Swiss-Prot
      Q9NNX6
      Conserved Domains (2) summary
      cd03590
      Location:120243
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam10018
      Location:38100
      Med4; Vitamin-D-receptor interacting Mediator subunit 4
    2. NM_001144894.1NP_001138366.1  CD209 antigen isoform 6

      See identical proteins and their annotated locations for NP_001138366.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks multiple exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter and lacks the transmembrane domain compared to isoform 1.
      Source sequence(s)
      AC008763, AK313585, AY042226
      Consensus CDS
      CCDS45949.1
      UniProtKB/TrEMBL
      B2R907
      UniProtKB/Swiss-Prot
      Q9NNX6
      Conserved Domains (1) summary
      cd03590
      Location:212335
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    3. NM_001144895.1NP_001138367.1  CD209 antigen isoform 7

      See identical proteins and their annotated locations for NP_001138367.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 7) compared to isoform 1. The encoded isoform (7) has 4.5 repeats in the neck domain.
      Source sequence(s)
      AC008763, AK313585, AY042223
      Consensus CDS
      CCDS45952.1
      UniProtKB/TrEMBL
      B2R907
      UniProtKB/Swiss-Prot
      Q9NNX6
      Conserved Domains (2) summary
      cd03590
      Location:164287
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam10018
      Location:82144
      Med4; Vitamin-D-receptor interacting Mediator subunit 4
    4. NM_001144896.1NP_001138368.1  CD209 antigen isoform 3

      See identical proteins and their annotated locations for NP_001138368.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter and lacks the transmembrane domain compared to isoform 1.
      Source sequence(s)
      AC008763, AK313585, AY042225
      Consensus CDS
      CCDS45950.1
      UniProtKB/TrEMBL
      B2R907
      UniProtKB/Swiss-Prot
      Q9NNX6
      Conserved Domains (1) summary
      cd03590
      Location:232355
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    5. NM_001144897.1NP_001138369.1  CD209 antigen isoform 4

      See identical proteins and their annotated locations for NP_001138369.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4) compared to isoform 1.
      Source sequence(s)
      AC008763, AK313585, AY042222
      Consensus CDS
      CCDS45951.1
      UniProtKB/TrEMBL
      B2R907
      UniProtKB/Swiss-Prot
      Q9NNX6
      Conserved Domains (2) summary
      cd03590
      Location:256373
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl01234
      Location:38184
      PilO; Pilus assembly protein, PilO
    6. NM_001144899.1NP_001138371.1  CD209 antigen isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 8) compared to isoform 1. The encoded isoform (8) has 1.5 repeats in the neck domain.
      Source sequence(s)
      AC008763, AK304190, AK313585
      Consensus CDS
      CCDS59345.1
      UniProtKB/TrEMBL
      B2R907
      UniProtKB/TrEMBL
      B4E2A8
      UniProtKB/TrEMBL
      X6RB12
      Conserved Domains (1) summary
      cd03590
      Location:95218
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    7. NM_021155.3NP_066978.1  CD209 antigen isoform 1

      See identical proteins and their annotated locations for NP_066978.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC008763, AK313585, AY042221
      Consensus CDS
      CCDS12186.1
      UniProtKB/TrEMBL
      B2R907
      UniProtKB/Swiss-Prot
      Q9NNX6
      Related
      ENSP00000315477, OTTHUMP00000269508, ENST00000315599, OTTHUMT00000462241
      Conserved Domains (2) summary
      cd03590
      Location:256379
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl01234
      Location:38184
      PilO; Pilus assembly protein, PilO

    RNA

    1. NR_026692.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC008763, AK313585, AY042229

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

      Range
      7739988..7747605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272472.3XP_005272529.1  

      Conserved Domains (1) summary
      cd03590
      Location:118241
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      7804605..7812189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)