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Hc hemolytic complement [ Mus musculus (house mouse) ]

Gene ID: 15139, updated on 25-Feb-2015
Official Symbol
Hcprovided by MGI
Official Full Name
hemolytic complementprovided by MGI
Primary source
MGI:MGI:96031
See related
Ensembl:ENSMUSG00000026874; Vega:OTTMUSG00000012274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C5; He; C5a
Orthologs
See Hc in MapViewer
Location:
2 23.22 cM; 2 cen-C1
Exon count:
41
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (34983331..35061441, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene TNF receptor-associated factor 1 Neighboring gene mitochondrial import receptor subunit TOM7 homolog Neighboring gene uncharacterized LOC105244126 Neighboring gene expressed sequence AI182371

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
complement activation, alternative pathway IEA
Inferred from Electronic Annotation
more info
 
complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
cytolysis IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemokine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane attack complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
complement C5
Names
complement C5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010406.2NP_034536.1  complement C5 preproprotein

    See proteins identical to NP_034536.1

    Status: VALIDATED

    Source sequence(s)
    AL845534, M35525
    Consensus CDS
    CCDS15957.1
    UniProtKB/Swiss-Prot
    P06684
    Related
    ENSMUSP00000028233, OTTMUSP00000013195, ENSMUST00000028233, OTTMUST00000029212
    Conserved Domains (9) summary
    cd00017
    Location:686754
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:9991304
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:776863
    A2M; Alpha-2-macroglobulin family
    pfam01835
    Location:125219
    A2M_N; MG2 domain
    pfam07677
    Location:14231513
    A2M_recep; A-macroglobulin receptor
    pfam07678
    Location:10551306
    A2M_comp; A-macroglobulin complement component
    pfam07703
    Location:474610
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    pfam11974
    Location:19111
    MG1; Alpha-2-macroglobulin MG1 domain
    cl02512
    Location:15311679
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    34983331..35061441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    34677654..34755968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)