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CCR7 chemokine (C-C motif) receptor 7 [ Homo sapiens (human) ]

Gene ID: 1236, updated on 11-Sep-2014
Official Symbol
CCR7provided by HGNC
Official Full Name
chemokine (C-C motif) receptor 7provided by HGNC
Primary source
HGNC:HGNC:1608
See related
Ensembl:ENSG00000126353; HPRD:02588; MIM:600242; Vega:OTTHUMG00000133375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7
Summary
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
See CCR7 in Epigenomics, MapViewer
Location:
17q12-q21.2
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (40553769..40565484, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38710021..38721736, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tensin 4 Neighboring gene uncharacterized LOC101059954 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 Neighboring gene keratin 222

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Inhibition of CpG-B-induced maturation of plasmacytoid dendritic cells by HIV-1 gp120 results in downregulation of CD40, CD83, CCR7, and HLA-DR expression PubMed
env HIV-1 gp120 interactions with CXCR4 and CCR5 lead to the cross-desensitization of CCR6 and CCR7; this gp120-induced inhibition is strictly dependent on CXCR4 or CCR5 and lipid rafts but not on CD4 or V(H)3-expressing BCR PubMed
env Stimulated HIV-1 infected CD4+ cells induce plasmacytoid dendritic cell (PDC) activation and maturation in a manner that is inhibited by antibodies to HIV-1 gp120; markers for PDC migration (CCR7) are enhanced during this process PubMed
Nef nef HIV-1 Nef-pulsed mDCs downregulate HLA-DR expression and upregulate CD25 and CCR7 expression in NK cells PubMed
Vif vif HIV-1 Vif upregulates the expression of chemokine (C-C motif) receptor 7 (CCR7) in Vif-expression T cells PubMed
matrix gag Treatment of plasmacytoid dendritic cells (pDCs) with HIV-1 MA upregulates the expression of CCR7. Coculture with MA and CCL19 induces a dose-dependent migration of pDCs PubMed

Go to the HIV-1, Human Interaction Database

  • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
    Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-C chemokine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
C-C motif chemokine 19 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
C-C motif chemokine 21 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G-protein coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
chemokine (C-C motif) ligand 19 binding IPI
Inferred from Physical Interaction
more info
PubMed 
chemokine (C-C motif) ligand 21 binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
activation of Rho GTPase activity IC
Inferred by Curator
more info
PubMed 
cellular response to cytokine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
chemokine (C-C motif) ligand 19 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
chemokine (C-C motif) ligand 21 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
chemokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic cell chemotaxis IC
Inferred by Curator
more info
PubMed 
establishment of T cell polarity IC
Inferred by Curator
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
interleukin-12 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
lymphocyte migration into lymph node TAS
Traceable Author Statement
more info
PubMed 
mature dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
myeloid dendritic cell chemotaxis IC
Inferred by Curator
more info
PubMed 
myeloid dendritic cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of leukocyte apoptotic process IC
Inferred by Curator
more info
PubMed 
negative thymic T cell selection IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IC
Inferred by Curator
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IC
Inferred by Curator
more info
PubMed 
positive regulation of JNK cascade IC
Inferred by Curator
more info
PubMed 
positive regulation of T cell costimulation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament polymerization IC
Inferred by Curator
more info
PubMed 
positive regulation of cell adhesion IC
Inferred by Curator
more info
PubMed 
positive regulation of cell motility IC
Inferred by Curator
more info
PubMed 
positive regulation of cell-matrix adhesion IC
Inferred by Curator
more info
PubMed 
positive regulation of cytosolic calcium ion concentration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of dendritic cell antigen processing and presentation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of dendritic cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of filopodium assembly IC
Inferred by Curator
more info
PubMed 
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of humoral immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hypersensitivity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of immunological synapse formation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
 
positive regulation of phosphatidylinositol 3-kinase activity IC
Inferred by Curator
more info
PubMed 
positive regulation of protein kinase B signaling IC
Inferred by Curator
more info
PubMed 
positive regulation of protein kinase activity IC
Inferred by Curator
more info
PubMed 
positive regulation of pseudopodium assembly IC
Inferred by Curator
more info
PubMed 
regulation of dendritic cell dendrite assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of interferon-gamma production ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of interleukin-1 beta secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
release of sequestered calcium ion into cytosol IC
Inferred by Curator
more info
PubMed 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to nitric oxide IC
Inferred by Curator
more info
PubMed 
response to prostaglandin E IC
Inferred by Curator
more info
PubMed 
ruffle organization IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
C-C chemokine receptor type 7
Names
C-C chemokine receptor type 7
MIP-3 beta receptor
CC chemokine receptor 7
Bukitt's lymphoma receptor 2
Epstein-Barr virus induced gene 1
EBV-induced G protein-coupled receptor 1
lymphocyte-specific G protein-coupled peptide receptor
Epstein-Barr virus-induced G-protein coupled receptor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301714.1NP_001288643.1  C-C chemokine receptor type 7 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    BC035343, BI910219, DA814913
  2. NM_001301716.1NP_001288645.1  C-C chemokine receptor type 7 isoform c precursor

    See proteins identical to NP_001288645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    AK310277, BC035343
  3. NM_001301717.1NP_001288646.1  C-C chemokine receptor type 7 isoform c precursor

    See proteins identical to NP_001288646.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    AK310277, BC035343, HY017993
  4. NM_001301718.1NP_001288647.1  C-C chemokine receptor type 7 isoform c precursor

    See proteins identical to NP_001288647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Variants 3, 4 and 5 all encode isoform c.
    Source sequence(s)
    BC035343, HY021417
  5. NM_001838.3NP_001829.1  C-C chemokine receptor type 7 isoform a precursor

    See proteins identical to NP_001829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC035343, DA814913, L31581
    Consensus CDS
    CCDS11369.1
    UniProtKB/TrEMBL
    A0N0Q0
    UniProtKB/Swiss-Prot
    P32248
    Related
    ENSP00000246657, OTTHUMP00000164532, ENST00000246657, OTTHUMT00000257222
    Conserved Domains (1) summary
    pfam00001
    Location:81326
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    40553769..40565484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    34504331..34516046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    38945325..38957040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)