Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    Thbs4 thrombospondin 4 [ Mus musculus (house mouse) ]

    Gene ID: 21828, updated on 27-Jun-2015
    Official Symbol
    Thbs4provided by MGI
    Official Full Name
    thrombospondin 4provided by MGI
    Primary source
    MGI:MGI:1101779
    See related
    Ensembl:ENSMUSG00000021702; Vega:OTTMUSG00000036725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TSP4
    Orthologs
    See Thbs4 in Epigenomics, MapViewer
    Location:
    13 C3; 13 47.75 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (92751586..92794818, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (93521541..93564773, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene serine incorporator 5 Neighboring gene predicted gene, 41018 Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene Neighboring gene metaxin 3 Neighboring gene predicted gene, 31630

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • , (from )
      ,
    • , (from )
      ,
    • , (from )
      ,
    • , (from )
      ,
    • , (from )
      ,
    • , (from )
      ,
    • , (from )
      ,
    • , (from )
      ,
    • , (from )
      ,
    • , (from )
      ,
    • , (from )
      ,
    • , (from )
      ,
    • , (from )
      ,

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    laminin-1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    behavioral response to pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral response to pain ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    myoblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of tissue remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    proteinaceous extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    thrombospondin-4
    Names
    thrombospondin-4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011582.3NP_035712.1  thrombospondin-4 precursor

      See identical proteins and their annotated locations for NP_035712.1

      Status: VALIDATED

      Source sequence(s)
      CT009509, CT025667
      Consensus CDS
      CCDS26684.1
      UniProtKB/TrEMBL
      B2RTL6
      UniProtKB/Swiss-Prot
      Q9Z1T2
      Related
      ENSMUSP00000022213, OTTMUSP00000052302, ENSMUST00000022213, OTTMUST00000094148
      Conserved Domains (7) summary
      pfam05735
      Location:747947
      TSP_C; Thrombospondin C-terminal region
      pfam11598
      Location:220264
      COMP; Cartilage oligomeric matrix protein
      pfam02412
      Location:499533
      TSP_3; Thrombospondin type 3 repeat
      cd00054
      Location:381415
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:602612
      TSP3; C-type Ca binding site_TSP3-short [ion binding]
      sd00002
      Location:498533
      TSP3; TSP3 repeat_long [structural motif]
      cl22861
      Location:26194
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

      Range
      92751586..92794818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000035.1 Alternate Mm_Celera

      Range
      96355385..96398324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)