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DUSP1 dual specificity phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 1843, updated on 11-Sep-2014
Official Symbol
DUSP1provided by HGNC
Official Full Name
dual specificity phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:3064
See related
Ensembl:ENSG00000120129; HPRD:02835; MIM:600714; Vega:OTTHUMG00000130523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HVH1; MKP1; CL100; MKP-1; PTPN10
Summary
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]
See DUSP1 in Epigenomics, MapViewer
Location:
5q34
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (172768090..172771200, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172195093..172198203, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 1B Neighboring gene microRNA 5003 Neighboring gene uncharacterized LOC101928093 Neighboring gene family with sequence similarity 58, member A pseudogene Neighboring gene endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 Neighboring gene uncharacterized LOC100268168 Neighboring gene ribosomal protein L26-like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of dual specificity protein phosphatase 1 (DUSP1) by siRNAs significantly enhances HIV-1 replication in human acute monocytic leukemia cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of dual specificity phosphatase 1 (DUSP1) in Vif-expression T cells PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP kinase tyrosine/serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
non-membrane spanning protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein tyrosine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
endoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
 
inactivation of MAPK activity ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle arrest ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-threonine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of mitotic cell cycle spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
response to light stimulus IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress TAS
Traceable Author Statement
more info
PubMed 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
dual specificity protein phosphatase 1
Names
dual specificity protein phosphatase 1
MAP kinase phosphatase 1
protein-tyrosine phosphatase CL100
dual specificity protein phosphatase hVH1
serine/threonine specific protein phosphatase
mitogen-activated protein kinase phosphatase 1
NP_004408.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004417.3NP_004408.1  dual specificity protein phosphatase 1

    See proteins identical to NP_004408.1

    Status: REVIEWED

    Source sequence(s)
    AA843403, AC022217, AK300487, BC022463
    Consensus CDS
    CCDS4380.1
    UniProtKB/TrEMBL
    B4DU40
    UniProtKB/Swiss-Prot
    P28562
    Related
    ENSP00000239223, OTTHUMP00000216442, ENST00000239223, OTTHUMT00000252943
    Conserved Domains (3) summary
    COG2453
    Location:188313
    CDC14; Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:173309
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:7136
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    172768090..172771200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    167290428..167293538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    171627607..171630717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)