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    NSs non-structural protein [ Rift Valley fever virus ]

    Gene ID: 9538292, updated on 6-Oct-2023

    Summary

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    Gene symbol
    NSs
    Gene description
    non-structural protein
    Locus tag
    RVFV_sS_gp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rift Valley fever virus (strain: ZH-548, nat-host: Homo sapiens)
    Lineage
    Viruses; ssRNA viruses; ssRNA negative-strand viruses; Bunyavirales; Phenuiviridae; Phlebovirus
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    Genomic context

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    Location:
    segment: S
    Sequence:
    NC_014395.1 (35..832)

    NC_014395.1Genomic Context describing neighboring genes Neighboring gene nucleocapsid

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_014395.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NSs Filament Formation Is Important but Not Sufficient for RVFV Virulence In Vivo. Li S, et al. Viruses, 2019 Sep 8. PMID 31500343, Free PMC Article
    2. Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments. Barski M, et al. Elife, 2017 Sep 15. PMID 28915104, Free PMC Article
    3. NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR. Kainulainen M, et al. J Virol, 2016 Jul 1. PMID 27122577, Free PMC Article
    4. Rift Valley fever virus NSS gene expression correlates with a defect in nuclear mRNA export. Copeland AM, et al. Virology, 2015 Dec. PMID 26410240
    5. Rift Valley fever virus NSs inhibits host transcription independently of the degradation of dsRNA-dependent protein kinase PKR. Kalveram B, et al. Virology, 2013 Jan 20. PMID 23063407, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The NSs Protein Encoded by the Virulent Strain of Rift Valley Fever Virus Targets the Expression of Abl2 and the Actin Cytoskeleton of the Host, Affecting Cell Mobility, Cell Shape, and Cell-Cell Adhesion.
      Title: The NSs Protein Encoded by the Virulent Strain of Rift Valley Fever Virus Targets the Expression of Abl2 and the Actin Cytoskeleton of the Host, Affecting Cell Mobility, Cell Shape, and Cell-Cell Adhesion.
    2. NSs Filament Formation Is Important but Not Sufficient for RVFV Virulence In Vivo.
      Title: NSs Filament Formation Is Important but Not Sufficient for RVFV Virulence In Vivo.
    3. The mutant Rift Valley fever virus-C39S/C40S showed an attenuated phenotype in mice. The results show that two mechanisms are responsible for the attenuation; (1) loss of the interferon antagonistic propriety characteristic of the wild-type NSs and (2) the inability of the attenuated mutant to degrade Proteine Kinase R (PKR).
      Title: Mutation of adjacent cysteine residues in the NSs protein of Rift Valley fever virus results in loss of virulence in mice.
    4. Recombinant virus encoding the NSs core domain induced intranuclear filaments, suggesting it contains all essential determinants for nuclear translocation and filament formation.
      Title: Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments.
    5. study found the F-box proteins FBXW11 and beta-TRCP1 to be relevant for the action of NSs against protein kinase PKR; identified the host cell factors that are critically needed by Rift Valley fever virus to uphold its replication against the potent antiviral kinase PKR.
      Title: NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR.
    6. Nuclear accumulation of host mRNA was not observed in cells infected with a strain of RVFV lacking the gene encoding NSS.
      Title: Rift Valley fever virus NSS gene expression correlates with a defect in nuclear mRNA export.
    7. Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH.
      Title: Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.
    8. These results suggest that production of the NSs protein during rift valley fever virus infection leads to sequestration of PABP1 in the nuclear speckles, creating a state within the cell that favors viral protein production.
      Title: Nuclear relocalization of polyadenylate binding protein during rift valley fever virus infection involves expression of the NSs gene.
    9. results suggest that NSs-mediated host general transcription suppression occurs independently of PKR degradation
      Title: Rift Valley fever virus NSs inhibits host transcription independently of the degradation of dsRNA-dependent protein kinase PKR.
    10. findings show that NSs targeted and modified the expression of genes coding for coagulation factors, demonstrating for the first time that this hemorrhagic virus impairs the host coagulation cascade at the transcriptional level
      Title: Large-scale chromatin immunoprecipitation with promoter sequence microarray analysis of the interaction of the NSs protein of Rift Valley fever virus with regulatory DNA regions of the host genome.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    non-structural protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_014395.1 Reference assembly

      Range
      35..832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_003848706.1 non-structural protein [Rift Valley fever virus]

      See identical proteins and their annotated locations for YP_003848706.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A2SZX2, P21698
      UniProtKB/TrEMBL
      A0A291B3W0, A2SZX6, A2SZY8, A2SZZ0, A2SZZ4
      Conserved Domains (1) summary
      pfam11073
      Location:5 → 242
      NSs; Rift valley fever virus non structural protein (NSs) like
    Nucleotide Protein
    Heading Accession and Version

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