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    Nkx6-1 NK6 homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 18096, updated on 17-Aug-2016
    Official Symbol
    Nkx6-1provided by MGI
    Official Full Name
    NK6 homeobox 1provided by MGI
    Primary source
    MGI:MGI:1206039
    See related
    Ensembl:ENSMUSG00000035187 Vega:OTTMUSG00000037547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NKX6A; Nkx6.1
    Orthologs
    Location:
    5; 5 E4
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (101659184..101664711, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (102088203..102093730, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29982 Neighboring gene predicted gene, 42132 Neighboring gene RIKEN cDNA 9430085M18 gene Neighboring gene predicted gene, 42133 Neighboring gene predicted gene, 42134

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    central nervous system neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocrine pancreas development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    oligodendrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of glial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    type B pancreatic cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    homeobox protein Nkx-6.1
    Names
    Drosophila NK transcription factor related, gene family 6, locus 1
    NK6 transcription factor related, locus 1
    homeobox protein NK-6 homolog A
    homeodomain transcription factor Nkx6.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144955.2NP_659204.1  homeobox protein Nkx-6.1

      See identical proteins and their annotated locations for NP_659204.1

      Status: PROVISIONAL

      Source sequence(s)
      AC105976
      Consensus CDS
      CCDS19471.1
      UniProtKB/Swiss-Prot
      Q99MA9
      Related
      ENSMUSP00000042716, OTTMUSP00000054116, ENSMUST00000044125, OTTMUST00000096793
      Conserved Domains (1) summary
      cd00086
      Location:238296
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      101659184..101664711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)