Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Mybpc3 myosin binding protein C, cardiac [ Mus musculus (house mouse) ]

    Gene ID: 17868, updated on 25-Aug-2016
    Official Symbol
    Mybpc3provided by MGI
    Official Full Name
    myosin binding protein C, cardiacprovided by MGI
    Primary source
    MGI:MGI:102844
    See related
    Ensembl:ENSMUSG00000002100 Vega:OTTMUSG00000014369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    2; 2 E1
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (91118114..91136516)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (90958301..90976673)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (metal ion transporter), member 13 Neighboring gene predicted gene, 39874 Neighboring gene spleen focus forming virus (SFFV) proviral integration oncogene Neighboring gene MAP-kinase activating death domain Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene acid phosphatase 2, lysosomal

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    myosin heavy chain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    myosin heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    A band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    A band ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin filament IEA
    Inferred from Electronic Annotation
    more info
     
    sarcomere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcomere ISO
    Inferred from Sequence Orthology
    more info
     
    striated muscle myosin thick filament ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    myosin-binding protein C, cardiac-type
    Names
    C-protein, cardiac muscle isoform
    cardiac C-protein
    cardiac MyBP-C

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008653.2NP_032679.2  myosin-binding protein C, cardiac-type

      See identical proteins and their annotated locations for NP_032679.2

      Status: VALIDATED

      Source sequence(s)
      AK146886
      Consensus CDS
      CCDS50631.1
      UniProtKB/TrEMBL
      Q3UIK0
      Related
      ENSMUSP00000127070, OTTMUSP00000015227, ENSMUST00000169776, OTTMUST00000033992
      Conserved Domains (7) summary
      cd00096
      Location:12021269
      Ig; Immunoglobulin domain
      cd05748
      Location:9941066
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd05894
      Location:660772
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:9851066
      IG_like; Immunoglobulin like
      cd00063
      Location:776866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:11851274
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:567633
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      91118114..91136516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239341.2XP_011237643.1  

      See identical proteins and their annotated locations for XP_011237643.1

      UniProtKB/TrEMBL
      Q3UIK0
      Conserved Domains (7) summary
      cd00096
      Location:12021269
      Ig; Immunoglobulin domain
      cd05748
      Location:9941066
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd05894
      Location:660772
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00410
      Location:9851066
      IG_like; Immunoglobulin like
      cd00063
      Location:776866
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:11851274
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:567633
      Ig; Immunoglobulin domain
    2. XM_006498882.3XP_006498945.1  

      Related
      ENSMUSP00000119994, OTTMUSP00000042060, ENSMUST00000137942, OTTMUST00000034060
      Conserved Domains (8) summary
      cd05748
      Location:9931065
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      cd05894
      Location:659771
      Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
      smart00408
      Location:11981260
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:9841065
      IG_like; Immunoglobulin like
      cd00063
      Location:775865
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:11841273
      I-set; Immunoglobulin I-set domain
      pfam00047
      Location:167251
      ig; Immunoglobulin domain
      cl11960
      Location:566632
      Ig; Immunoglobulin domain