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    Cp ceruloplasmin [ Mus musculus (house mouse) ]

    Gene ID: 12870, updated on 17-Sep-2016
    Official Symbol
    Cpprovided by MGI
    Official Full Name
    ceruloplasminprovided by MGI
    Primary source
    MGI:MGI:88476
    See related
    Ensembl:ENSMUSG00000003617 Vega:OTTMUSG00000023513
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D3Ertd555e
    Summary
    The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
    Orthologs
    Location:
    3; 3 D
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (19956985..20009750)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (19857054..19907609)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 320-like Neighboring gene predicted gene, 42190 Neighboring gene Hermansky-Pudlak syndrome 3 Neighboring gene helicase-like transcription factor Neighboring gene glycogenin

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    ferroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    copper ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    anchored component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    blood microparticle ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ceruloplasmin
    Names
    ferroxidase
    NP_001263177.1
    NP_001263179.1
    NP_031778.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276248.1NP_001263177.1  ceruloplasmin isoform c precursor

      See identical proteins and their annotated locations for NP_001263177.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate, in-frame acceptor splice site as well as an alternate 3' exon structure, compared to variant 2. It encodes isoform c which is longer and has a distinct C-terminus, compared to isoform b. Both variants 3 and 4 encode the same isoform (c).
      Source sequence(s)
      AK043248, AK086999, BC062957
      Consensus CDS
      CCDS71227.1
      UniProtKB/Swiss-Prot
      Q61147
      UniProtKB/TrEMBL
      G3X8Q5, Q8BU82
      Related
      ENSMUSP00000103964, OTTMUSP00000027619, ENSMUST00000108328, OTTMUST00000057276
      Conserved Domains (5) summary
      cd04224
      Location:369566
      CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
      cd04225
      Location:726896
      CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
      cd11021
      Location:213353
      CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
      cd11022
      Location:569712
      CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
      cl19115
      Location:22201
      Cupredoxin; Cupredoxin superfamily
    2. NM_001276250.1NP_001263179.1  ceruloplasmin isoform c precursor

      See identical proteins and their annotated locations for NP_001263179.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate, in-frame acceptor splice site as well as an alternate 3' exon structure, compared to variant 2. It encodes isoform c which is longer and has a distinct C-terminus, compared to isoform b. Both variants 3 and 4 encode the same isoform (c).
      Source sequence(s)
      AC079442
      Consensus CDS
      CCDS71227.1
      UniProtKB/TrEMBL
      G3X8Q5
      Related
      ENSMUSP00000003714, OTTMUSP00000027618, ENSMUST00000003714, OTTMUST00000057275
      Conserved Domains (5) summary
      cd04224
      Location:369566
      CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
      cd04225
      Location:726896
      CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
      cd11021
      Location:213353
      CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
      cd11022
      Location:569712
      CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
      cl19115
      Location:22201
      Cupredoxin; Cupredoxin superfamily
    3. NM_007752.3NP_031778.2  ceruloplasmin isoform b precursor

      See identical proteins and their annotated locations for NP_031778.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform b.
      Source sequence(s)
      BC062957, BE689746
      Consensus CDS
      CCDS38401.1
      UniProtKB/Swiss-Prot
      Q61147
      Related
      ENSMUSP00000088857, OTTMUSP00000027617, ENSMUST00000091309, OTTMUST00000057274
      Conserved Domains (5) summary
      cd04224
      Location:369567
      CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
      cd04225
      Location:727897
      CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
      cd11021
      Location:213353
      CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
      cd11022
      Location:570713
      CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
      cl19115
      Location:22201
      Cupredoxin; Cupredoxin superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      19956985..20009750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249655.2XP_011247957.1  

      See identical proteins and their annotated locations for XP_011247957.1

      UniProtKB/TrEMBL
      E9PZD8
      Related
      ENSMUSP00000103965, ENSMUST00000108329
      Conserved Domains (5) summary
      cd04224
      Location:369567
      CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
      cd04225
      Location:727897
      CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
      cd11021
      Location:213353
      CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
      cd11022
      Location:570713
      CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
      cl19115
      Location:22201
      Cupredoxin; Cupredoxin superfamily
    2. XM_006535381.3XP_006535444.1  

      See identical proteins and their annotated locations for XP_006535444.1

      UniProtKB/TrEMBL
      E9PZD8
      Conserved Domains (5) summary
      cd04224
      Location:369567
      CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
      cd04225
      Location:727897
      CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
      cd11021
      Location:213353
      CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
      cd11022
      Location:570713
      CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
      cl19115
      Location:22201
      Cupredoxin; Cupredoxin superfamily
    3. XM_017319446.1XP_017174935.1  

      Related
      ENSMUSP00000103961, OTTMUSP00000027652, ENSMUST00000108325, OTTMUST00000057343
      Conserved Domains (5) summary
      cd04224
      Location:369566
      CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
      cd04225
      Location:726896
      CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
      cd11021
      Location:213353
      CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
      cd11022
      Location:569712
      CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
      cl19115
      Location:22201
      Cupredoxin; Cupredoxin superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001042611.1: Suppressed sequence

      Description
      NM_001042611.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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