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Lepr leptin receptor [ Mus musculus (house mouse) ]

Gene ID: 16847, updated on 20-Apr-2015
Official Symbol
Leprprovided by MGI
Official Full Name
leptin receptorprovided by MGI
Primary source
MGI:MGI:104993
See related
Ensembl:ENSMUSG00000057722; Vega:OTTMUSG00000008454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
db; Obr; obl; Leprb; Modb1; LEPROT; OB-RGRP; diabetes; obese-like
Orthologs
See Lepr in MapViewer
Location:
4 C6; 4 46.96 cM
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (101717407..101815354)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (101390012..101487959)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 6 Neighboring gene predicted gene, 36012 Neighboring gene leptin receptor overlapping transcript Neighboring gene RIKEN cDNA B020004J07 gene Neighboring gene growth factor receptor bound protein 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Leptin Insulin Overlap, organism-specific biosystem (from WikiPathways)
    Leptin Insulin Overlap, organism-specific biosystemOverlap of cellular insulin and leptin signaling
  • Leptin and adiponectin, organism-specific biosystem (from WikiPathways)
    Leptin and adiponectin, organism-specific biosystemProposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.].
  • Mus musculus biological processes, organism-specific biosystem (from REACTOME)
    Mus musculus biological processes, organism-specific biosystemCertain mouse pathways have been fully manually curated in Reactome in order to support the manual inference of well-conserved but less well-studied human pathways. These pathways include Circadian...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
    Signaling by Leptin, organism-specific biosystemLeptin, a circulating adipokine, and its receptor Lepr control food intake and energy balance (recently reviewed in Wauman and Tavernier 2011, Bjorbaek 2009, Morris and Rui 2009, Myers et al. 2008). ...
  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
    Signaling by Leptin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC105189

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
eating behavior ISO
Inferred from Sequence Orthology
more info
 
leptin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of hydrolase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of metabolic process TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
leptin receptor
Names
leptin receptor
B219
LEP-R
OB receptor
leptin receptor gene-related protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122899.1NP_001116371.1  leptin receptor isoform 3 precursor

    See proteins identical to NP_001116371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 3' exon, as compared to variant 1. The resultign isoform (3) has a different and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK140785, BC082551, CJ319649, CN692760, U42467
    Consensus CDS
    CCDS51239.1
    UniProtKB/Swiss-Prot
    P48356
    UniProtKB/TrEMBL
    Q3US58
    UniProtKB/TrEMBL
    Q640Q2
    Related
    ENSMUSP00000102534, OTTMUSP00000008797, ENSMUST00000106921, OTTMUST00000019186
    Conserved Domains (2) summary
    cd00063
    Location:236328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:332420
    Lep_receptor_Ig; Ig-like C2-type domain
  2. NM_010704.2NP_034834.1  leptin receptor isoform 2 precursor

    See proteins identical to NP_034834.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the 3' exon but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a different and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK143989, CN692760
    Consensus CDS
    CCDS18397.1
    UniProtKB/Swiss-Prot
    P48356
    UniProtKB/TrEMBL
    Q3UNU8
    Related
    ENSMUSP00000099838, OTTMUSP00000008795, ENSMUST00000102777, OTTMUST00000019184
    Conserved Domains (2) summary
    cd00063
    Location:236328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:332420
    Lep_receptor_Ig; Ig-like C2-type domain
  3. NM_146146.2NP_666258.2  leptin receptor isoform 1 precursor

    See proteins identical to NP_666258.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    CN692760, U46135
    Consensus CDS
    CCDS51240.1
    UniProtKB/Swiss-Prot
    P48356
    Related
    ENSMUSP00000037385, OTTMUSP00000008794, ENSMUST00000037552, OTTMUST00000019183
    Conserved Domains (2) summary
    cd00063
    Location:236328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06328
    Location:332420
    Lep_receptor_Ig; Ig-like C2-type domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    101717407..101815354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    100061452..100155523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)