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    Tmem173 transmembrane protein 173 [ Mus musculus (house mouse) ]

    Gene ID: 72512, updated on 13-Sep-2016
    Official Symbol
    Tmem173provided by MGI
    Official Full Name
    transmembrane protein 173provided by MGI
    Primary source
    MGI:MGI:1919762
    See related
    Ensembl:ENSMUSG00000024349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ERIS; MPYS; Mita; STING; 2610307O08Rik
    Orthologs
    Location:
    18; 18 B3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (35733678..35740554, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (35893332..35900208, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene RIKEN cDNA 1700066B19 gene Neighboring gene 40S ribosomal protein S25 Neighboring gene ubiquitin-conjugating enzyme E2D 2A

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cyclic-GMP-AMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclic-GMP-AMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclic-di-GMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclic-di-GMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interferon-beta IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription factor import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    stimulator of interferon genes protein
    Names
    endoplasmic reticulum interferon stimulator
    mediator of IRF3 activation
    mitochondrial mediator of IRF3 activation

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289591.1NP_001276520.1  stimulator of interferon genes protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 5' exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AC132837, AK089405, BB871885
      UniProtKB/Swiss-Prot
      Q3TBT3
      Conserved Domains (1) summary
      pfam15009
      Location:93385
      TMEM173; Transmembrane protein 173
    2. NM_001289592.1NP_001276521.1  stimulator of interferon genes protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC132837, AK012006, AK089405, AK158458, BB871885
      UniProtKB/Swiss-Prot
      Q3TBT3
      Conserved Domains (1) summary
      pfam15009
      Location:44295
      TMEM173; Transmembrane protein 173
    3. NM_028261.1NP_082537.1  stimulator of interferon genes protein isoform 1

      See identical proteins and their annotated locations for NP_082537.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC132837, AK077788, AK089405, AK158458, BB872463
      Consensus CDS
      CCDS50253.1
      UniProtKB/Swiss-Prot
      Q3TBT3
      Related
      ENSMUSP00000111393, ENSMUST00000115728
      Conserved Domains (1) summary
      pfam15009
      Location:44336
      TMEM173; Transmembrane protein 173

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      35733678..35740554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317994.1XP_017173483.1  

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