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    DIS3 exosome catalytic subunit DIS3 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854138, updated on 3-Apr-2016
    Gene symbol
    DIS3
    Gene description
    exosome catalytic subunit DIS3
    Primary source
    SGD:S000005381
    Locus tag
    YOL021C
    Gene type
    protein coding
    RNA name
    exosome catalytic subunit DIS3
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MTR17; RRP44
    See DIS3 in Map Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (282421..285426, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tsr4p Neighboring gene tRNA Neighboring gene aromatic amino acid transmembrane transporter TAT2 Neighboring gene tRNA

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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    • Exosome, eukaryotes, organism-specific biosystem (from KEGG)
      Exosome, eukaryotes, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • Exosome, eukaryotes, conserved biosystem (from KEGG)
      Exosome, eukaryotes, conserved biosystemStructural complex; Genetic information processing; RNA processing
    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    3'-5'-exoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    3'-5'-exoribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ncRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nonfunctional rRNA decay IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear mRNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear polyadenylation-dependent CUT catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear polyadenylation-dependent mRNA catabolic process IC
    Inferred by Curator
    more info
    PubMed 
    nuclear polyadenylation-dependent rRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear polyadenylation-dependent tRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear polyadenylation-dependent tRNA catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nuclear polyadenylation-dependent tRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IC
    Inferred by Curator
    more info
    PubMed 
    nuclear-transcribed mRNA catabolic process, non-stop decay IC
    Inferred by Curator
    more info
    PubMed 
    polyadenylation-dependent snoRNA 3'-end processing IC
    Inferred by Curator
    more info
    PubMed 
    rRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    exosome catalytic subunit DIS3
    NP_014621.1
    • Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      282421..285426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183275.1NP_014621.1  exosome catalytic subunit DIS3 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_014621.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q08162
      Conserved Domains (3) summary
      cd09862
      Location:25221
      PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
      COG0557
      Location:281989
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:531862
      RNB; RNB domain