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ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I [ Homo sapiens (human) ]

Gene ID: 117, updated on 21-Jul-2014
Official Symbol
ADCYAP1R1provided by HGNC
Official Full Name
adenylate cyclase activating polypeptide 1 (pituitary) receptor type Iprovided by HGNC
Primary source
HGNC:242
See related
Ensembl:ENSG00000078549; HPRD:00045; MIM:102981; Vega:OTTHUMG00000023884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAC1; PAC1R; PACAPR; PACAPRI
Summary
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
See ADCYAP1R1 in Epigenomics, MapViewer
Location:
7p14
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (31052461..31111479)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (31092076..31151093)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene aquaporin 1 (Colton blood group) Neighboring gene growth hormone releasing hormone receptor Neighboring gene uncharacterized LOC101928310 Neighboring gene neuronal differentiation 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.
NHGRI GWA Catalog
  • Activation of TRKA receptors, organism-specific biosystem (from REACTOME)
    Activation of TRKA receptors, organism-specific biosystemTrk receptors can either be activated by neurotrophins or by two G-protein-coupled receptors (GPCRs) although the biological relevance of GPCRs remains to be shown.
  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class B Secretin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class B Secretin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Glucagon-type ligand receptors, organism-specific biosystem (from REACTOME)
    Glucagon-type ligand receptors, organism-specific biosystemThe glucagon hormone family regulates the activity of GPCRs from the secretin receptor subfamily in Class II/B (Mayo KE et al, 2003).
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • NGF-independant TRKA activation, organism-specific biosystem (from REACTOME)
    NGF-independant TRKA activation, organism-specific biosystemTRK receptors can also be activated by at least two G-protein-coupled receptors (GPCR), the adenosine A2a receptor and the PACAP type I receptor, without involvement of neurotrophins. Activity of bo...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP-ribosylation factor binding IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase binding IEA
Inferred from Electronic Annotation
more info
 
neuropeptide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
vasoactive intestinal polypeptide receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
 
activation of phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
development of primary female sexual characteristics IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal response to stress IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of calcium ion transport into cytosol IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
caveola IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
tight junction IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
pituitary adenylate cyclase-activating polypeptide type I receptor
Names
pituitary adenylate cyclase-activating polypeptide type I receptor
PACAP-R1
PACAP receptor 1
PACAP type I receptor
pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029869.1 

    Range
    5001..64018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001118.4NP_001109.2  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 3 precursor

    See proteins identical to NP_001109.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC006466, AK290046, CA432770, DA809763
    Consensus CDS
    CCDS5433.1
    UniProtKB/Swiss-Prot
    P41586
    Related
    ENSP00000306620, OTTHUMP00000123435, ENST00000304166, OTTHUMT00000215041
    Conserved Domains (2) summary
    pfam00002
    Location:150396
    Blast Score: 847
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52137
    Blast Score: 216
    HRM; Hormone receptor domain
  2. NM_001199635.1NP_001186564.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 precursor

    See proteins identical to NP_001186564.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC006466, BC136267, CA432770, DA809763
    Consensus CDS
    CCDS56480.1
    UniProtKB/Swiss-Prot
    P41586
    Conserved Domains (2) summary
    pfam00002
    Location:150424
    Blast Score: 827
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52137
    Blast Score: 214
    HRM; Hormone receptor domain
  3. NM_001199636.1NP_001186565.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 2 precursor

    See proteins identical to NP_001186565.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.
    Source sequence(s)
    AC006466, BC143679, CA432770, DA809763
    UniProtKB/Swiss-Prot
    P41586
    Conserved Domains (2) summary
    pfam00002
    Location:150423
    Blast Score: 827
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52137
    Blast Score: 214
    HRM; Hormone receptor domain
  4. NM_001199637.1NP_001186566.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 4 precursor

    See proteins identical to NP_001186566.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two consecutive exons in the upstream region and one exon in the downstream region in the CDS, as compared to variant 1. The resulting isoform (3) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AC006466, AK226138, CA432770, DA809763
    Consensus CDS
    CCDS56481.1
    UniProtKB/Swiss-Prot
    P41586
    Conserved Domains (2) summary
    pfam00002
    Location:129375
    Blast Score: 841
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52116
    Blast Score: 237
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    31052461..31111479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715645.1XP_006715708.1  

    Conserved Domains (2) summary
    pfam00002
    Location:150424
    Blast Score: 832
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52137
    Blast Score: 217
    HRM; Hormone receptor domain
  2. XM_006715646.1XP_006715709.1  

    Conserved Domains (2) summary
    pfam00002
    Location:143417
    Blast Score: 826
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52130
    Blast Score: 221
    HRM; Hormone receptor domain
  3. XM_006715647.1XP_006715710.1  

    UniProtKB/Swiss-Prot
    P41586
    Conserved Domains (2) summary
    pfam00002
    Location:129403
    Blast Score: 820
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52116
    Blast Score: 235
    HRM; Hormone receptor domain
  4. XM_006715648.1XP_006715711.1  

    Conserved Domains (2) summary
    pfam00002
    Location:93367
    Blast Score: 815
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:4680
    Blast Score: 110
    HRM; Hormone receptor domain
  5. XM_005249618.2XP_005249675.1  

    UniProtKB/Swiss-Prot
    P41586
    Conserved Domains (2) summary
    pfam00002
    Location:93339
    Blast Score: 834
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:4680
    Blast Score: 111
    HRM; Hormone receptor domain

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    30974048..31033016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    31091676..31150684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)