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    G6pc2 glucose-6-phosphatase, catalytic, 2 [ Mus musculus (house mouse) ]

    Gene ID: 14378, updated on 22-Dec-2015
    Official Symbol
    G6pc2provided by MGI
    Official Full Name
    glucose-6-phosphatase, catalytic, 2provided by MGI
    Primary source
    MGI:MGI:1277193
    See related
    Ensembl:ENSMUSG00000005232; Vega:OTTMUSG00000012981
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IGRP; G6pc-rs
    Summary
    This gene encodes an enzyme that belongs to the glucose-6-phosphatase catalytic subunit family. Members of this family catalyze the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, to release glucose into the bloodstream. The family member encoded by this gene is found specifically in pancreatic islets but has not been shown to have phosphotransferase or phosphatase activity exhibited by a similar liver enzyme. The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes, an autoimmune disease in which T lymphocytes attack and destroy insulin-producing pancreatic beta cells. In NOD mice, the protein encoded by this gene is a major target of cell-mediated autoimmunity. Variations in the human and mouse genes are associated with lower fasting plasma glucose levels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Orthologs
    See G6pc2 in Epigenomics, MapViewer
    Location:
    2 C2; 2 39.66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (69211073..69227993)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (69058055..69066045)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene nitric oxide synthase trafficker Neighboring gene SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 11 Neighboring gene predicted gene, 36393 Neighboring gene dehydrogenase/reductase (SDR family) member 9

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT glucose-6-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    integral component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    glucose-6-phosphatase 2
    Names
    G-6-Pase 2
    glucose-6-phosphatase, catalytic, related sequence
    islet-specific glucose-6-phosphatase catalytic subunit-related protein
    NP_001276785.1
    NP_001276786.1
    NP_067306.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289856.1NP_001276785.1  glucose-6-phosphatase 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK148465, BP758187, BQ557220
      UniProtKB/Swiss-Prot
      Q9Z186
      Conserved Domains (1) summary
      cl00474
      Location:1162
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
    2. NM_001289857.1NP_001276786.1  glucose-6-phosphatase 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks an alternate exon in the coding region resulting in a frameshift and an early stop codon compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK148450, BP758187
      Consensus CDS
      CCDS71066.1
      UniProtKB/Swiss-Prot
      Q9Z186
      Related
      ENSMUSP00000107936, OTTMUSP00000013988, ENSMUST00000112317, OTTMUST00000031265
      Conserved Domains (1) summary
      cl00474
      Location:38138
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
    3. NM_021331.4NP_067306.1  glucose-6-phosphatase 2 isoform 1

      See identical proteins and their annotated locations for NP_067306.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK148450, AK148465, BP758187
      Consensus CDS
      CCDS16089.1
      UniProtKB/Swiss-Prot
      Q9Z186
      Related
      ENSMUSP00000005364, OTTMUSP00000013987, ENSMUST00000005364, OTTMUST00000031263
      Conserved Domains (2) summary
      COG0671
      Location:36193
      PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
      cd03381
      Location:38278
      PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

      Range
      69211073..69227993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      70877278..70894213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)