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    Grm5 glutamate receptor, metabotropic 5 [ Mus musculus (house mouse) ]

    Gene ID: 108071, updated on 23-Aug-2015
    Official Symbol
    Grm5provided by MGI
    Official Full Name
    glutamate receptor, metabotropic 5provided by MGI
    Primary source
    MGI:MGI:1351342
    See related
    Ensembl:ENSMUSG00000049583; Vega:OTTMUSG00000016489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glu5R; Gprc1e; mGluR5; mGluR5b; AI850523; 6430542K11Rik
    Orthologs
    See Grm5 in Epigenomics, MapViewer
    Location:
    7; 7 E1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (87583981..88135063)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (94732678..95283573)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene NADPH oxidase 4 Neighboring gene tyrosinase Neighboring gene splicing factor 3a, subunit 1 pseudogene Neighboring gene cathepsin C Neighboring gene predicted gene 2407

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    A2A adenosine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    PLC activating G-protein coupled glutamate receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPKKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    cognition ISO
    Inferred from Sequence Orthology
    more info
     
    desensitization of G-protein coupled receptor protein signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of locomotion ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase C-activating G-protein coupled glutamate receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    astrocyte projection ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    metabotropic glutamate receptor 5
    Names
    G protein coupled receptor, family C, group 1, member E
    G protein-coupled receptor GRM5
    G protein-coupled receptor, family C, group 1, member E
    metabotropic glutamate receptor subtype 5b
    metabotropic glutamate receptor type 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081414.2NP_001074883.1  metabotropic glutamate receptor 5 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) lacks an alternate in-frame exon in the 3' coding region, compared to variant b. The resulting isoform (a) lacks a segment near the C-terminus, compared to isoform b.
      Source sequence(s)
      AC113033, BC096533, BC144727, BY721282, CJ124875
      Consensus CDS
      CCDS40013.1
      UniProtKB/TrEMBL
      B7ZMP7
      UniProtKB/TrEMBL
      E9QMC2
      UniProtKB/TrEMBL
      Q4VA56
      Related
      ENSMUSP00000118393, OTTMUSP00000017749, ENSMUST00000125009, OTTMUST00000039787
      Conserved Domains (5) summary
      cd06374
      Location:26496
      PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
      pfam10606
      Location:11211171
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
      pfam00003
      Location:588824
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:67471
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:507557
      NCD3G; Nine Cysteines Domain of family 3 GPCR
    2. NM_001143834.1NP_001137306.1  metabotropic glutamate receptor 5 isoform b precursor

      See identical proteins and their annotated locations for NP_001137306.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) represents the longer transcript and encodes the longer isoform (b).
      Source sequence(s)
      AC113033, AC116820, BC096533, BY721282, CJ124875
      Consensus CDS
      CCDS52305.1
      UniProtKB/TrEMBL
      B2BH30
      UniProtKB/Swiss-Prot
      Q3UVX5
      UniProtKB/TrEMBL
      Q4VA56
      Conserved Domains (5) summary
      cd06374
      Location:26496
      PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
      pfam10606
      Location:11531203
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
      pfam00003
      Location:588824
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:67471
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:507557
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

      Range
      87583981..88135063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241643.1XP_011239945.1  

      See identical proteins and their annotated locations for XP_011239945.1

      UniProtKB/TrEMBL
      B2BH30
      UniProtKB/Swiss-Prot
      Q3UVX5
      Conserved Domains (5) summary
      cd06374
      Location:26496
      PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
      pfam10606
      Location:11531203
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
      pfam00003
      Location:588824
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:67471
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:507557
      NCD3G; Nine Cysteines Domain of family 3 GPCR
    2. XM_006507184.2XP_006507247.1  

      Related
      ENSMUSP00000129181, ENSMUST00000167164
      Conserved Domains (4) summary
      cd06374
      Location:26496
      PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
      pfam00003
      Location:588824
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:67471
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:507557
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      84945210..85487922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033224.1: Suppressed sequence

      Description
      NM_001033224.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.