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Scn4a sodium channel, voltage-gated, type IV, alpha [ Mus musculus (house mouse) ]

Gene ID: 110880, updated on 11-Sep-2014
Official Symbol
Scn4aprovided by MGI
Official Full Name
sodium channel, voltage-gated, type IV, alphaprovided by MGI
Primary source
MGI:98250
See related
Ensembl:ENSMUSG00000001027; Vega:OTTMUSG00000003417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mH2; SkM1; Nav1.4
See Scn4a in Epigenomics, MapViewer
Location:
11 E1; 11 68.91 cM
Exon count:
26
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (106317545..106365475, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene growth hormone Neighboring gene CD79B antigen Neighboring gene uncharacterized LOC102639981 Neighboring gene RIKEN cDNA 2310007L24 gene

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cation transport ISO
Inferred from Sequence Orthology
more info
 
choline transport ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
membrane depolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
neuronal action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
voltage-gated sodium channel complex IC
Inferred by Curator
more info
PubMed 
Preferred Names
sodium channel protein type 4 subunit alpha
Names
sodium channel protein type 4 subunit alpha
sodium channel alpha-subunit
sodium channel protein type IV subunit alpha
voltage-gated sodium channel subunit alpha Nav1.4
sodium channel protein skeletal muscle subunit alpha
sodium channel, voltage-gated, type IV, alpha polypeptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133199.2NP_573462.2  sodium channel protein type 4 subunit alpha

    See proteins identical to NP_573462.2

    Status: VALIDATED

    Source sequence(s)
    AL604045, BC129805
    Consensus CDS
    CCDS48961.1
    UniProtKB/TrEMBL
    G3X8T7
    UniProtKB/Swiss-Prot
    Q9ER60
    Related
    ENSMUSP00000021056, OTTMUSP00000003451, ENSMUST00000021056, OTTMUST00000007190
    Conserved Domains (3) summary
    cd13433
    Location:12901342
    Blast Score: 301
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:10611288
    Blast Score: 464
    Ion_trans; Ion transport protein
    pfam06512
    Location:8101035
    Blast Score: 618
    Na_trans_assoc; Sodium ion transport-associated

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    106317545..106365475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531987.1XP_006532050.1  

    See proteins identical to XP_006532050.1

    UniProtKB/TrEMBL
    G3X8T7
    Conserved Domains (3) summary
    cd13433
    Location:12901342
    Blast Score: 301
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:10611288
    Blast Score: 464
    Ion_trans; Ion transport protein
    pfam06512
    Location:8101035
    Blast Score: 618
    Na_trans_assoc; Sodium ion transport-associated
  2. XM_006531988.1XP_006532051.1  

    See proteins identical to XP_006532051.1

    UniProtKB/TrEMBL
    G3X8T7
    Conserved Domains (3) summary
    cd13433
    Location:12901342
    Blast Score: 301
    Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
    pfam00520
    Location:10611288
    Blast Score: 464
    Ion_trans; Ion transport protein
    pfam06512
    Location:8101035
    Blast Score: 618
    Na_trans_assoc; Sodium ion transport-associated

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    118049260..118080125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)